PMID: 6172352Jan 1, 1982Paper

Antiviral treatment of chronic hepatitis B virus infection: infectious virus cannot be detected in patient serum after permanent responses to treatment

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
G H ScullardW S Robinson

Abstract

Fourteen chimpanzees were inoculated with pre- and posttreatment sera from seven patients with persistent hepatitis B virus infection and chronic hepatitis who had permanent responses of their infection to treatment with interferon and/or adenine arabinoside. Inoculation of pretreatment serum at a dilution of 10(-8) from a patient with a Type I response to treatment [disappearance of Dane particle DNA polymerase (DNAP) activity, HBeAg, and HBsAg from serum] resulted in infection, while undiluted posttreatment serum (all markers negative) failed to infect another animal. Pretreatment sera (DNAP, HBeAg, and HBsAg positive) from all six patients with a Type II response to treatment (disappearance of DNAP activity and HBeAg but not HBsAg from serum) led to infection in six chimpanzees after inoculation of serum dilutions varying between 10(-2) and 10(-7). Inoculation of undiluted posttreatment sera (HBsAg positive and DNAP and HBeAg negative) from the same six patients produced no evidence of hepatitis B virus infection in another six animals. These results indicate that a Type I or II response to treatment with these antiviral agents reduces the infectivity in the serum of patients with chronic hepatitis B to below the level of de...Continue Reading

References

Jul 1, 1975·The American Journal of the Medical Sciences·J H HoffnagleL F Barker
Jan 1, 1977·Journal of Medical Virology·J F Hruska, W S Robinson
Jun 22, 1978·The New England Journal of Medicine·J H HoofnagleH J Zimmerman
Jan 18, 1979·The New England Journal of Medicine·S KrugmanF Deinhardt
Oct 1, 1977·The Journal of Infectious Diseases·T ShikataY Moritsugu
Sep 2, 1976·The New England Journal of Medicine·H B GreenbergT C Merigan
Oct 1, 1975·The Journal of Infectious Diseases·L F BarkerD H Krushak
Jun 1, 1973·The Journal of Infectious Diseases·L F BarkerM R Peterson
May 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G H ScullardP B Gregory
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P L MarionW S Robinson
Apr 1, 1980·Journal of Virology·C Albin, W S Robinson

❮ Previous
Next ❯

Citations

Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HoofnagleH Popper
Mar 1, 1986·Postgraduate Medicine·D K Sarver
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F ImazekiK Okuda
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G DusheikoM Kew
Sep 3, 1984·Klinische Wochenschrift·K GmelinB Kommerell
Mar 7, 1983·FEBS Letters·L FiumeA Mattioli
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H PopperJ H Hoofnagle
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P L MarionW S Robinson
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T C Merigan
Jan 1, 1986·Antimicrobial Agents and Chemotherapy·M EisenbergT C Merigan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.