Antiviral treatment with pegylated interferon and clinical outcomes in a cohort of immigrants patients affected by hepatitis delta: A retrospective analysis

Journal of Medical Virology
Lucio BoglioneGiovanni Di Perri

Abstract

Chronic hepatitis delta (CHD) is the most severe chronic hepatitis, with no satisfactory treatment options and severe clinical outcomes. This infection is frequent in the migrant subjects from endemic areas, especially from Africa and East-Europe. The pegylated (PEG)-interferon α (IFN) is limited by side effects and poor response. In this retrospective analysis, we reported our experience of treatment with PEG-IFN in a cohort of immigrant patients affected by CHD. We evaluated the virological responses are as follows: complete response (CR; clearance of hepatitis B surface antigen [HBsAg] and hepatitis D virus [HDV]-RNA), partial response (PR; HBsAg clearance with HDV-RNA+), and null response (NR; HBsAg and HDV-RNA+). Clinical outcomes were clinical stabilization, disease progression, hepatic decompensation, hepatocellular carcinoma (HCC), death, and liver transplantation. Forty-six patients were included. At the end of treatment (ET), 11 patients gained a CR (23.9%), 10 were PR (21.7%), and 16 were NR (34.8%). After 1 year, 10 remained with CR (21.7%), after 2 years, 9 (19.5%), and at 3 years, 8 (17.4%). Relapse rate was 2.2%, 4.4%, and 6.5% at year 1, 2, and 3, respectively. Favorable factors were CR at the ET (odds ratio [OR...Continue Reading

References

Jan 28, 2011·The New England Journal of Medicine·Heiner WedemeyerUNKNOWN HIDIT Study Group
Jan 26, 2012·Alimentary Pharmacology & Therapeutics·C TriantosA Burroughs
Jan 23, 2013·The American Journal of Tropical Medicine and Hygiene·Pablo RivasSabino Puente
Apr 12, 2013·Journal of Gastroenterology and Hepatology·Robert G GishJeffrey S Glenn
Dec 3, 2013·Current Gastroenterology Reports·Mazen Noureddin, Robert Gish
Mar 4, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin HeidrichUNKNOWN HIDIT-1 Study Group
Mar 19, 2014·The Journal of Infection·Lucio BoglioneAntonio D'Avolio
May 13, 2014·Alimentary Pharmacology & Therapeutics·T HellerJ H Hoofnagle
Nov 5, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Ioannis GoulisGeorge Papatheodoridis
Jul 23, 2016·Alimentary Pharmacology & Therapeutics·G A NiroM Rizzetto
Oct 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anika WrankeHeiner Wedemeyer
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver

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