Antler extracts stimulate chondrocyte proliferation and possess potent anti-oxidative, anti-inflammatory, and immune-modulatory properties

In Vitro Cellular & Developmental Biology. Animal
Baojin YaoYu Zhao

Abstract

The Sika deer antler is well known for its unique ability to regenerate repeatedly and grow rapidly. Furthermore, it is a precious traditional Chinese medicine and has been widely used for more than 20 centuries. The major bioactive components within the antlers are water-soluble proteins, polypeptides, and free amino acids. Many studies have shown that water-soluble antler extracts play pivotal roles in wound healing, immune system modulation, anti-oxidation, and anti-inflammation. However, the exact effects on chondrocytes are still largely unknown. In this study, we prepared fresh, aqueous extracts from growing deer antlers in a rapid growth stage. We isolated the chondrocytes from neonatal mouse rib cartilage and investigated the effects of antler extracts on chondrocyte viability. We also used the RNA-Seq method to analyze the gene expression pattern under antler extract treatment. We demonstrated that fresh extracts from Sika deer antlers in a rapid growth stage significantly promoted chondrocyte viability and kept chondrocytes proliferating continuously, while blocking maturation and further differentiation. Additionally, our results indicated that antler extracts might serve as a potent anti-oxidant, anti-inflammatory a...Continue Reading

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Citations

Nov 6, 2018·Genome Génome / Conseil National De Recherches Canada·Baojin YaoYu Zhao
Jan 8, 2021·Journal of Orthopaedic Surgery and Research·Baojin YaoDaqing Zhao
Mar 27, 2021·Journal of Proteome Research·Zhen Dong, Dawn Coates

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Datasets Mentioned

BETA
SRP125924

Methods Mentioned

BETA
RNA-Seq
protein assay
FCS
PCR

Software Mentioned

BLAST
HISAT
DEGseq

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