PMID: 9160198Apr 1, 1997Paper

Antral and fundic D-cell numbers in Helicobacter pylori infection

European Journal of Gastroenterology & Hepatology
P ChamouardR Baumann

Abstract

Helicobacter pylori infection is associated with an exaggeration of gastrin release following meals or bombesin stimulation attributed to a defect of somatostatin secretion of antral D-cells. Nevertheless, these modifications of gastric physiology do not explain the increase of gastric acid secretion which is only observed in duodenal ulcer patients. The inhibitory effect of somatostatin secretion of fundic D-cells on parietal cells is well known. The aim of our prospective study was to compare the number of fundic D-cells and likewise the number of antral G-cells and D-cells between patients with duodenal ulcer and healthy subjects with and without H. pylori infection. The numbers of D-cells and G-cells were compared between 19 infected patients with duodenal ulcer and 20 healthy subjects, 10 with and 10 without H. pylori infection. Fundic mucosal biopsy specimens were examined using immunohistochemical techniques specific for the presence of somatostatin, antral mucosal biopsy specimens for the presence of gastrin and somatostatin. The number of G-cells was significantly lower (P = 0.0012) in duodenal ulcer patients by comparison with infected subjects and controls. The number of antral D-cells was significantly less (P < 0.0...Continue Reading

Citations

May 6, 2008·Regulatory Peptides·Edith Mensah-OsmanJuanita L Merchant
Jan 28, 2015·World Journal of Gastroenterology : WJG·Ya-Nan GongJian-Zhong Zhang
Jul 15, 2005·World Journal of Gastroenterology : WJG·Aleksandra Sokic-MilutinovicOlivera Mitrovic
Apr 2, 2002·World Journal of Gastroenterology : WJG·Feng-Peng SunYong-Li Yao

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