Antral vascular lesion, achlorhydria, and chronic gastrointestinal blood loss: response to steroids

Digestive Diseases and Sciences
J Calam, R J Walker

Abstract

A 72-year-old female gave a history of chronic gastrointestinal blood loss necessitating transfusion with over 90 units of blood despite continuous oral iron therapy over a period of 24 years. Gastroscopic appearances were very similar to those recently described by Lewis and by Wheeler in patients with submucosal angiomatous lesions and chronic gastrointestinal blood loss. Striking erythematous streaks radiated from the pylorus and were confined to the antrum. In our case complete achlorhydria to pentagastrin was associated with low serum and antral gastrin concentrations. The introduction of oral prednisolone was followed by a marked fall in the rate of gastrointestinal blood loss, removing the need for transfusion during the following year. Complete achlorhydria persisted and endoscopic appearances remained unchanged, but there was a marked rise in antral and serum gastrin concentrations. The possible modes of action of prednisolone in this case are discussed. The patient remains well in November 1979. The dose of prednisolone was reduced to 10 mg on alternate days in May 1979. Iron supplements have been continued but no transfusion has been required since the start of steroid therapy. The hemoglobin has gradually risen to 1...Continue Reading

References

May 1, 1976·The American Journal of Digestive Diseases·S RaptisE F Pfeiffer
Feb 1, 1979·Digestive Diseases and Sciences·M H WheelerB W Lawrie
May 1, 1978·The American Journal of Digestive Diseases·T D LewisR L Goodacre
Nov 20, 1971·British Medical Journal·R G StricklandJ Hansky
Mar 1, 1968·The Journal of Pediatrics·N C Fost, N B Esterly
Jul 17, 1953·Annals of the New York Academy of Sciences·B W ZWEIFACHM M BLACK

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Citations

Jan 1, 1992·Lasers in Surgery and Medicine·D J Bjorkman, K N Buchi
Jan 1, 1995·Abdominal Imaging·G F BarnardB F Banner
Jun 1, 1989·Digestive Diseases and Sciences·J H GilliamJ E Richter
Apr 1, 1984·Gastrointestinal Endoscopy·F I LeeK S Vasudev
Oct 24, 2009·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Janeil M BelleTheodore N Pappas
Sep 1, 1996·Journal of Gastroenterology and Hepatology·M J BourkeS J Williams
Jun 1, 1997·Journal of Gastroenterology and Hepatology·M Nishioka, S A Morshed
May 1, 1991·The Australian and New Zealand Journal of Surgery·M N MerrettC J Martin
Sep 1, 1990·Postgraduate Medical Journal·R H ParkR I Russell
Apr 1, 1994·Postgraduate Medical Journal·M M el-OmarR P Thompson
Oct 1, 1994·Postgraduate Medical Journal·I L Beales
Dec 25, 2012·Clinical Medicine & Research·Papia KarCamille F Torbey
Sep 1, 1994·Gastrointestinal Endoscopy·S M LiberskiD Reynolds
Jul 1, 1990·Gastrointestinal Endoscopy·K F Binmoeller, R M Katon
Jul 1, 1989·Gastrointestinal Endoscopy·J L Petrini, J H Johnston
Jul 19, 2003·Alimentary Pharmacology & Therapeutics·S SebastianM J M Buckley
Sep 1, 1996·Gastrointestinal Endoscopy·R W TobinG B McDonald
Nov 26, 1999·Gastrointestinal Endoscopy·M GürsoyS Boyacioğlu
Dec 17, 2014·Gastroenterología y hepatología·Meritxell CasasRafael Campo
Mar 12, 2010·Annals of Saudi Medicine·Baris YildizVolkan Kaynaroglu
Apr 3, 2018·Journal of Translational Internal Medicine·Abdulrahman M AlkhormiAbdullah Alqarawi
Jul 1, 1998·The American Journal of Gastroenterology·J E Gretz, S R Achem
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I M Samloff
Feb 9, 2006·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Kathleen M ReganLee Vorderer
Mar 17, 2012·Japanese Journal of Clinical Oncology·Ehab Saad AldinArafat Tfayli
Dec 22, 2007·Journal of Clinical Gastroenterology·Ellen C Ebert
Apr 1, 1991·The British Journal of Surgery·R H Park, R I Russell
Jan 1, 1986·Journal of the Royal Society of Medicine·H S CairnsG Bevan
Dec 1, 1991·Gastroenterologia Japonica·K KishiM Fukase
Jun 23, 1986·The Medical Journal of Australia·W D RawlinsonB P Lin

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