Antrocamphin A, an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus , and its mechanisms

Journal of Agricultural and Food Chemistry
Yu-Hsin HsiehSheng-Yang Wang

Abstract

The fungus Taiwanofungus camphoratus is commonly used for medicinal purposes in Taiwan. It is used as a detoxicant for food poisoning and considered to be a precious folk medicine for hepatoprotection and anti-inflammation. In this study, a lipopolysaccaride (LPS)-challenged ICR mouse acute inflammation model and a LPS-induced macrophage model were used to evaluate the anti-inflammatory activity of T. camphoratus. Ethanol extract of T. camphoratus significantly inhibited expression of iNOS and COX-2 in the liver of LPS-challenged acute inflammatory mice. The ethyl acetate fraction and its isolated compound, antrocamphin A, significantly suppressed nitrite/nitrate concentration in LPS-challenged RAW 264.7 cells. Antrocamphin A showed potent anti-inflammatory activity by suppressing pro-inflammatory molecule release via the down-regulation of iNOS and COX-2 expression through the NF-kappaB pathway. This study, therefore, first demonstrates the bioactive compound of T. camphoratus and illustrates the mechanism by which it confers its anti-inflammatory activity.

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Citations

Aug 6, 2011·Acta Pharmacologica Sinica·Zhen-ming Lu, Zheng-hong Xu
Jan 9, 2013·BMC Pharmacology & Toxicology·Chung-Hang LeungDik-Lung Ma
Sep 6, 2012·International Journal of Molecular Sciences·Yu-Ren LiaoTian-Shung Wu
Apr 9, 2013·Pharmacology & Therapeutics·Mei-Chin LuYang-Chang Wu
Oct 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mei-Yeh Jade LuWen-Hsiung Li
Jun 28, 2011·Journal of Ethnopharmacology·Chi-Luan WenGuan-Jhong Huang
Jan 5, 2014·Organic & Biomolecular Chemistry·Marco BucciniMatthew J Piggott
Jul 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yude WangChangjun Lv

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