Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-kappaB activation in transgenic mice evaluated by bioluminescence imaging

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
You-Cheng HseuChien-Yun Hsiang

Abstract

In an earlier study, we found that Antrodia camphorata inhibited the production of lipopolysaccharide (LPS)-induced cytokines, inducible nitric oxide synthase, and cyclooxygenase-2 by blocking nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages. This study was aimed at evaluating the inhibitory effects of the fermented culture broth of A. camphorata in terms of LPS-induced NF-kappaB activation in transgenic mice by using a non-invasive, real-time NF-kappaB bioluminescence imaging technique. Transgenic mice carrying the luciferase gene under the control of NF-kappaB were given A. camphorata (570 mg/kg, p.o.) for three consecutive days and then injected with LPS (4 mg/kg, i.p.). In vivo imaging showed that treatment with LPS increased the luminescent signal, whereas A. camphorata suppressed the LPS-induced inflammatory response significantly. Ex vivo imaging showed that A. camphorata suppressed LPS-induced NF-kappaB activity in the small intestine, mesenteric lymph nodes, liver, spleen, and kidney. Immunohistochemical staining revealed that A. camphorata suppressed production of the LPS-induced tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and NF-kappaB p65 subunit in these org...Continue Reading

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Citations

Oct 11, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·You-Cheng HseuHsin-Ling Yang
Apr 23, 2011·Bioscience, Biotechnology, and Biochemistry·Chia-Yu ChangJiunn-Jye Chuu
Apr 9, 2013·Pharmacology & Therapeutics·Mei-Chin LuYang-Chang Wu
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yu-Tang TungChuan-Mu Chen
Feb 11, 2015·Applied Microbiology and Biotechnology·Chun-Lin Lee
May 27, 2014·Journal of Ethnopharmacology·Tsung-Teng HuangHsin-Chih Lai
Jun 13, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chia-Cheng LiTin-Yun Ho
Dec 3, 2014·Journal of Ethnopharmacology·Tung-Chou TsaiChuan-Mu Chen
Nov 9, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsin-Ling YangYou-Cheng Hseu
Nov 13, 2018·Organic & Biomolecular Chemistry·Xiaoming WangXiaoguang Lei
Jul 7, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsin-Ling YangYou-Cheng Hseu

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