Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice

Oncotarget
Tse-Hung HuangChang-Jer Wu

Abstract

Whereas cisplatin (cis-diamminedichloroplatinum II) is a first-line medicine to treat solid cancerous tumors, it often causes serious side effects. New medicines that have an equivalent or even better therapeutic effect but with free or less side effects than cisplatin are highly anticipated in cancer therapy. Recent reports revealed that Antrodia cinnamomea (AC) possesses hepatoprotective activity in addition to anticancer. In this study, we wanted to know whether AC enhances chemo-sensitivity of cisplatin and/or alleviates cisplatin-induced hepatotoxicity, as well as the underlying mechanisms thereof. Our results indicated that AC inhibited proliferation of line-1 lung carcinoma cells and rescued hepatic HepG2 cells from cisplatin-induced cell death in vitro. The fact is that AC and cisplatin synergized to constrain growth of line-1 lung carcinoma cells in BALB/cByJ mice. Quantitative real-time PCR further revealed that AC promoted expression of apoptosis-related genes, while it decreased expression of NF-κB and VEGF in tumor tissues. In liver, AC reduced cisplatin-induced liver dysfunctions, liver inflammation and hepatic apoptosis in addition to body weight restoration. In summary, AC is able to increase cisplatin efficacy ...Continue Reading

References

Mar 1, 1988·Biochemical Pharmacology·J Robak, R J Gryglewski
Mar 26, 1998·Toxicology and Applied Pharmacology·J LiuC D Klaassen
Sep 19, 2003·Seminars in Nephrology·Istvan Arany, Robert L Safirstein
Feb 27, 2004·Oncogene·Damodaran ChendilMansoor M Ahmed
Oct 19, 2004·Cancer Letters·Thambi Dorai, Bharat B Aggarwal
Feb 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giannicola D'AddarioFrances A Shepherd
Jun 24, 2005·The New England Journal of Medicine·Timothy WintonUNKNOWN National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators
Jan 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael McCullochJohn M Colford
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carmela PepeUNKNOWN National Cancer Institute of Canada and Intergroup Study JBR.10
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Nov 17, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hak-Ryul KimRaekil Park
Dec 8, 2007·Toxicology Letters·Yolanda I ChirinoJosé Pedraza-Chaverri
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre PignonUNKNOWN LACE Collaborative Group
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David JackmanVincent A Miller
Mar 9, 2012·Cell Biology International·Vildan B CetintasZuhal Eroglu
Dec 29, 2012·Recent Patents on Food, Nutrition & Agriculture·Yu-Fen ChenGwo-Fang Yuan
Apr 9, 2013·Pharmacology & Therapeutics·Mei-Chin LuYang-Chang Wu
Nov 13, 2013·The Journal of Clinical Investigation·Soumen RoyLisa L Cunningham
Jan 11, 2014·Seminars in Cancer Biology·Ana CostaFatima Mechta-Grigoriou
Oct 1, 2012·Journal of Traditional and Complementary Medicine·Yen-Wenn LiuLee-Yan Sheen
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yi-Ren ChenChing-Feng Weng
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Yenny PrasajaRetnosari Andrajati

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Citations

Feb 20, 2019·International Journal of Molecular Sciences·Tsu-Hsiang KuoShuang-En Chuang
May 14, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Li Liu, Chen Wang
Jun 21, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C-J ChangJ D Young
Dec 29, 2020·International Journal of Biological Macromolecules·Mei-Kuang LuChia-Chuan Chang
Apr 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abdullah Alyoussef, Mohammed M H Al-Gayyar

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Methods Mentioned

BETA
PCR
nitric oxide assay

Software Mentioned

SPSS
Statistical Software Package for the Social Sciences

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