Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma

Scientific Reports
Wei-De WuJui-Hsiang Hung

Abstract

Hepatocellular carcinoma (HCC) has been recognized worldwide as one of the major causes of cancer death. The medicinal fungus Antrodia cinnamomea (A. cinnamomea) has been served as a functional food for liver protection. The aim of the present study was to investigate the potential activity of A. cinnamomea extracts as a safe booster for the anticancer activity of sorafenib, a multi-kinase inhibitor approved for the treatment of HCC. The biologically active triterpenoids in the ethanolic extracts of A. cinnamomea (EAC) were initially identified by HPLC/LC/MS then the different extracts and sorafenib were assessed in vitro and in vivo. EAC could effectively sensitize HCC cells to low doses of sorafenib, which was perceived via the ability of the combination to repress cell viability and to induce cell cycle arrest and apoptosis in HCC cells. The ability of EAC to enhance sorafenib activity was mediated through targeting mitogen-activated protein (MAP) kinases, modulating cyclin proteins expression and inhibiting cancer cell invasion. Moreover, the proposed combination significantly suppressed ectopic tumor growth in mice with high safety margins compared to single-agent treatment. Thus, this study highlights the advantage of com...Continue Reading

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Citations

May 14, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Li Liu, Chen Wang
Jul 24, 2020·Acta Pharmacologica Sinica·Zhong-Jie LiGuo-Dong Lu
Aug 2, 2019·Journal of Food Biochemistry·Nagarajan GanesanNguyen Chi Thanh
Jul 23, 2021·Journal of Chemotherapy·Mandeep Dahiya, Harish Dureja

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Methods Mentioned

BETA
flow cytometry
PCR
zymography
xenograft
fluorescence microscopy
xenografts

Software Mentioned

ImageJ
GraphPad InStat
Image J
GraphPad Prism
GraphPad
Calcusyn

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