Antrodia salmonea-induced oxidative stress abrogates HER-2 signaling cascade and enhanced apoptosis in ovarian carcinoma cells

Journal of Cellular Physiology
Hsin-Ling YangYou-Cheng Hseu

Abstract

Antrodia salmonea is well known in Taiwan as a traditional Chinese medicinal fungus and has demonstrated antioxidant, anti-inflammatory, and anticancer effects. However, the anticancer activity of A. salmonea against human ovarian cancer is still elusive. Therefore, we investigated the antiovarian tumor activity of a fermented culture broth of A. salmonea and exhibits its underlying molecular mechanism. A. salmonea shows a significant effect on cell viability in human ovarian carcinoma (SKOV-3 or A2780) cell lines with an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Increased terminal deoxynucleotidyl transferase dUTP nick-end labeling-positive cells and annexin V-propidium iodide stained cells indicate that A. salmonea induces late apoptosis in SKOV-3 cells. Notably, treatment with A. salmonea induced the following events: Apoptosis; caspase-3, -8, -9 and poly(ADP-ribose) polymerase activation; first apoptosis signal (Fas) and Fas ligand activation; Bid cleavage; and Bax2-B-cell lymphoma 2 dysregulation. The results show that A. salmonea-induced apoptosis was mediated by both mitochondrial and death receptor pathways. An increase in intracellular reactive oxygen species (ROS) was also observed in A. salm...Continue Reading

References

Mar 21, 2001·Apoptosis : an International Journal on Programmed Cell Death·H U SimonF Levi-Schaffer
Jul 9, 2002·Apoptosis : an International Journal on Programmed Cell Death·C Soldani, A Ivana Scovassi
Jun 11, 2004·Annual Review of Biochemistry·Xuejun Jiang, Xiaodong Wang
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GariG Stanimir
Sep 4, 2007·Planta medica·Chien-Chang ShenYuh-Chiang Shen
Sep 15, 2007·Antioxidants & Redox Signaling·Abdulrahman K Doughan, Sergey I Dikalov
Dec 13, 2007·Nature Reviews. Molecular Cell Biology·Rebecca C TaylorSeamus J Martin
Oct 3, 2008·Anti-cancer Drugs·Tiffany J Somers-Edgar, Rhonda J Rosengren
Jan 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Eugenia Guicciardi, Gregory J Gores
May 25, 2010·Japanese Journal of Clinical Oncology·Chun-Ju ChiangUNKNOWN Taiwan Cancer Registry Task Force
Nov 13, 2010·Cell Death and Differentiation·Z T SchugE Gottlieb
Mar 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Joan T GarrettCarlos L Arteaga
Feb 14, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Guan-Jhong HuangChieh-Hsi Wu
Apr 3, 2013·Cold Spring Harbor Perspectives in Biology·David R McIlwainTak W Mak
Apr 23, 2013·Journal of Cancer Research and Clinical Oncology·Clara NatoliTeresa Gamucci
May 2, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Si-Yuan PanKam-Ming Ko
Dec 5, 2013·World Journal of Clinical Cases·Yoshihito Yokoyama, Hideki Mizunuma
Apr 29, 2014·Biochimica Et Biophysica Acta·Haidar AklGeert Bultynck
Jun 3, 2014·Molecular Cancer·Jian MaBolin Liu
Oct 3, 2014·Molecular Biology International·Nida Iqbal, Naveed Iqbal
Feb 28, 2015·Environmental Toxicology and Pharmacology·Aneta Rogalska, Agnieszka Marczak
Mar 29, 2016·PloS One·Mashitoh Abd RahmanNajihah Mohd Hashim
Feb 22, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chia-Ting ChangHsin-Ling Yang
Mar 4, 2017·International Journal of Cancer. Journal International Du Cancer·S B CoburnB Trabert

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