Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-[Formula: see text]B and Nrf2 Pathways

The American Journal of Chinese Medicine
I-Chuan YenShih-Yu Lee

Abstract

Antrodia cinnamomea, a medicinal mushroom, has previously demonstrated anti-inflammatory activity, although the specific compound responsible for the effect remains unclear. The present study was designed to investigate the anti-inflammatory property of antrolone, a novel benzoid derived from A. cinnamomea mycelium, and to clarify the underlying mechanisms of action. To this end, murine macrophage RAW264.7 cells were treated with antrolone (0.1-30[Formula: see text][Formula: see text]M) 30[Formula: see text]min prior to stimulation with lipopolysaccharides (LPS, 0.1[Formula: see text][Formula: see text]g/ml) for 24[Formula: see text]h. Cell viability, nitric oxide (NO) and prostaglandin E2 (PGE2) production, levels of pro-inflammatory cytokines and chemokines, and the signaling pathways involved in the inflammatory cascades were then investigated. Our results show that antrolone significantly decreased LPS-induced NO, PGE2, pro-inflammatory cytokine, and keratinocyte chemoattractant CXCL1 (KC) production and reduced levels of the proteins inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). These effects were independent of the effect of antrolone on macrophage cytotoxicity. Moreover, antrolone significantly inhibited the...Continue Reading

References

Sep 23, 1994·Cell·C Nathan, Q W Xie
Jul 1, 1996·American Journal of Respiratory Cell and Molecular Biology·A M Choi, J Alam
Jun 15, 2007·Journal of Natural Products·Jih-Jung ChenPo-Chuen Shieh
Feb 29, 2008·Cytokine·Yong-Chen LuPamela S Ohashi
Jun 21, 2008·American Journal of Respiratory Cell and Molecular Biology·Masaru SuzukiMasaharu Nishimura
Jul 23, 2008·Journal of Agricultural and Food Chemistry·Shih-Chang ChienYueh-Hsiung Kuo
Aug 19, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Madamanchi Geethangili, Yew-Min Tzeng
Feb 5, 2010·Journal of Agricultural and Food Chemistry·Yu-Hsin HsiehSheng-Yang Wang
Jul 21, 2010·Biochemical Pharmacology·Ananta PaineStephan Immenschuh
Jan 22, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Keiko TaguchiMasayuki Yamamoto
May 25, 2013·Nature Reviews. Immunology·Eicke LatzAndrea Stutz
Sep 12, 2013·Redox Biology·Emilia KansanenAnna-Liisa Levonen
Nov 2, 2013·World Journal of Hepatology·Clarice Silvia Taemi Origassa, Niels Olsen Saraiva Câmara
Jan 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Hung ChiuRobert Y Peng
Feb 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Fon ChenTian-Shung Wu
Mar 8, 2014·Frontiers in Immunology·Vincent Piras, Kumar Selvarajoo
May 27, 2014·Journal of Ethnopharmacology·Tsung-Teng HuangHsin-Chih Lai
Apr 4, 2015·Experimental & Molecular Medicine·A-Jin LeeJae-Hong Kim
Sep 30, 2016·BMJ : British Medical Journal·Andrea ArfèUNKNOWN Safety of Non-steroidal Anti-inflammatory Drugs (SOS) Project Consortium
Aug 24, 2017·The American Journal of Chinese Medicine·Li-Yen HuangShih-Yu Lee

❮ Previous
Next ❯

Citations

Sep 26, 2020·International Journal of Molecular Sciences·Chia-Hsin WuShih-Yu Lee
Nov 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingyi HouXi Li
Aug 2, 2019·Journal of Food Biochemistry·Nagarajan GanesanNguyen Chi Thanh
Mar 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I-Chuan YenShih-Yu Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here