Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammatory Status in a Mouse Model of Crohn's Disease

Neuroscience
Arya Haj-MirzaianAhmad Reza Dehpour

Abstract

Depression and anxiety are common comorbid disorders observed in patients with inflammatory bowel disease (IBD). Increasing line of evidence indicates that immune-inflammatory responses are involved in co-occurrence of mood disorders and IBD. However, the mechanisms through which immune-inflammatory pathways modulate this comorbidity are not yet understood. This study investigated the role of innate immunity in the development of behavioral abnormalities associated with an animal model of Crohn's disease (CD). To do this, we induced colitis in male adult mice by intrarectal (i.r.) injection of DNBS (Dinitrobenzene sulfonic acid). After 3 days, we performed behavioral tests for anxiety- and depressive-like behaviors as well as tissue collection. Our results showed that DNBS-induced colonic inflammatory responses were accompanied by infiltration of inflammatory cells, and increased expression of genes involved in toll-like receptor signaling pathway in intestinal tissue. Furthermore, the DNBS-treated mice showed depressive- and anxiety-like behaviors which were associated with increased expression of the inflammatory genes and abnormal mitochondrial function in the hippocampus. These results suggest that peripheral inflammation i...Continue Reading

References

Mar 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·G MagniA Martin
Mar 21, 2000·International Reviews of Immunology·M NeurathW Strober
Apr 25, 2000·Annual Review of Medicine·K A Papadakis, S R Targan
Nov 7, 2000·Biological Psychiatry·R S DumanC D'Sa
Apr 12, 2001·The European Journal of Neuroscience·L VutskitsJ Z Kiss
Sep 13, 2001·Journal of Epidemiology and Community Health·L M KurinaL E Gill
Mar 18, 2003·The Journal of Physiology·Lysa BoisséQuentin J Pittman
May 13, 2005·The Tohoku Journal of Experimental Medicine·Ali CetinkayaMehmet Akif Buyukbese
Sep 3, 2005·Nature Reviews. Drug Discovery·John F Cryan, Andrew Holmes
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Cesare MancusoVittorio Calabrese
Mar 16, 2007·Brain, Behavior, and Immunity·Michael R Irwin, Andrew H Miller
May 25, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M El Gazzar
Jun 26, 2007·Clinical and Experimental Immunology·H E BarksbyJ J Taylor
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rana Al-SadiThomas Y Ma
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kiarash RiaziQuentin J Pittman
Oct 10, 2009·Nature Protocols·Mariusz R WieckowskiPaolo Pinton
Jan 16, 2010·Nature Reviews. Microbiology·Lautaro Diacovich, Jean-Pierre Gorvel
Feb 11, 2010·Human & Experimental Toxicology·Amir Hossein AbdolghaffariMohammad Abdollahi
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael Maes
Aug 20, 2010·Inflammatory Bowel Diseases·Laura M MacknerWallace V Crandall
Sep 2, 2010·Neuroscience Research·Iiris HovattaJonas Donner
Dec 20, 2011·Trends in Neurosciences·Andre Der-Avakian, Athina Markou

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Citations

Oct 20, 2018·PLoS Biology·Christine HägerAndré Bleich
Jul 30, 2019·Clinical and Experimental Pharmacology & Physiology·Maryam ZakeriMohammad Allahtavakoli
Nov 12, 2019·Frontiers in Pediatrics·Yue SunHailong Cao
Feb 13, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ning ZhangShuguang Yu
Oct 9, 2020·Cellular and Molecular Neurobiology·Olga A LyubashinaSergey S Panteleev
Jan 28, 2021·Journal of Clinical Medicine·Spyros PeppasStefanos Bonovas
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Arvin Haj-MirzaianAhmad Reza Dehpour
Jun 30, 2021·Drug and Chemical Toxicology·Hamed GhavimiMir-Jamal Hosseini
Jun 2, 2021·The Journal of Surgical Research·Mohamad M MoughnyehColin A Martin
Oct 28, 2021·Neurochemical Research·Soroush BijaniMir-Jamal Hosseini

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