Anxiety and Brain Mitochondria: A Bidirectional Crosstalk

Trends in Neurosciences
Michaela D Filiou, Carmen Sandi

Abstract

Accumulating data highlight the contribution of brain mitochondria and bioenergetics to psychiatric disorders and stress-related pathologies. Although anxiety has not received much attention in this booming literature, a bidirectional interplay between anxiety and brain mitochondria and metabolism has recently started to emerge. Substantial observations indicate alterations in mitochondria and metabolism in highly anxious individuals and, conversely, anxiety symptoms in humans suffering from mitochondrial disorders. Genetic and pharmacological efforts have made substantial progress at advancing the causal involvement of specific mitochondrial and metabolic factors in anxiety. In this review, we discuss this converging evidence and highlight the relevance of developing a research focused on targeting mitochondria as an approach to alleviate anxiety.

Citations

Dec 12, 2019·Frontiers in Endocrinology·Shumsuzzaman Khan
Aug 28, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sashaina E Fanibunda, Vidita A Vaidya
Nov 23, 2019·Physiological Research·M Ľupták, J Hroudová
Oct 3, 2020·The European Journal of Neuroscience·Karla-Gerlinde SchrautMathias V Schmidt
Dec 5, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maria Serena PaladiniRaffaella Molteni
Jan 24, 2021·Mitochondrion·Emily K ZitkovskyAudrey R Tyrka
Jul 12, 2020·Neuroscience and Biobehavioral Reviews·Martin Picard, Carmen Sandi
Feb 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Latika NagpalSolomon H Snyder
Mar 17, 2021·Cellular and Molecular Neurobiology·Valentina L Savchenko
Nov 24, 2020·The European Journal of Neuroscience·Angeliki-Maria VlaikouMichaela D Filiou
Mar 17, 2021·Biological Psychiatry·Amalia Floriou-ServouJohannes Bohacek
Jun 6, 2021·Psychopharmacology·Thiago Garcia VargaTatiana Rosado Rosenstock
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Jul 6, 2021·Journal of Alzheimer's Disease : JAD·Luodan YangQuanguang Zhang
Jul 12, 2021·Translational Psychiatry·Gal Richter-Levin, Carmen Sandi
Aug 8, 2021·International Journal of Molecular Sciences·Soon-Ae KimEun-Hye Jang
Aug 9, 2021·Molecular Neurobiology·Matej ĽuptákJana Hroudová
Sep 24, 2021·Stress : the International Journal on the Biology of Stress·Aikaterini IliouMichaela D Filiou

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