Anxiety and Epigenetics

Advances in Experimental Medicine and Biology
Andrew A BartlettR G Hunter

Abstract

Anxiety disorders are highly prevalent psychiatric disorders often comorbid with depression and substance abuse. Twin studies have shown that anxiety disorders are moderately heritable. Yet, genome-wide association studies (GWASs) have failed to identify gene(s) significantly associated with diagnosis suggesting a strong role for environmental factors and the epigenome. A number of anxiety disorder subtypes are considered "stress related." A large focus of research has been on the epigenetic and anxiety-like behavioral consequences of stress. Animal models of anxiety-related disorders have provided strong evidence for the role of stress on the epigenetic control of the hypothalamic-pituitary-adrenal (HPA) axis and of stress-responsive brain regions. Neuroepigenetics may continue to explain individual variation in susceptibility to environmental perturbations and consequently anxious behavior. Behavioral and pharmacological interventions aimed at targeting epigenetic marks associated with anxiety may prove fruitful in developing treatments.

Citations

Jan 23, 2019·The International Journal of Neuropsychopharmacology·Anupam SahNicolas Singewald
Oct 22, 2019·Communications Biology·Melanie D MarkStefan Herlitze
Oct 24, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Simranjot KaurAmteshwar Singh Jaggi
Jun 30, 2018·Molecular Psychiatry·Gabor EgervariYasmin L Hurd
Apr 18, 2019·International Journal of Molecular Sciences·Natalia LesiewskaMaciej Bieliński
Aug 23, 2020·Brain Sciences·Matteo VismaraBernardo Dell'Osso
Aug 31, 2019·Pharmacology & Therapeutics·Simone B Sartori, Nicolas Singewald
Sep 29, 2019·Journal of Psychiatric Research·Julia TomasiArun K Tiwari
Jan 12, 2020·Communications Biology·Melanie D MarkStefan Herlitze
Dec 2, 2020·The Journal of Investigative Dermatology·Yu Sawada, Richard L Gallo
Aug 6, 2021·Acta Neuropsychiatrica·Amanda J SalesSâmia R L Joca
May 22, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tâmie DuarteDenis B Rosemberg
Aug 28, 2021·International Journal of Environmental Research and Public Health·Dorota OrtenburgerJacek Wąsik

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