Anxiety and ethanol consumption in victorious and defeated mice; effect of kappa-opioid receptor activation

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
N N KudryavtsevaJan M Van Ree

Abstract

Alcohol consumption and addiction have been related to anxiety and the anxiolytic effect of ethanol. It has been shown in mice that losers with repeated experience of social defeats are more anxious than winners with repeated experience of victories. Mice with a different social status were tested for their oral ethanol consumption using a free two bottle choice paradigm and for their social approach behaviour after ethanol consumption using the partition test, in which anxiety is an important component. In addition, the sensitivity of the animals for the kappa-opioid receptor agonist U-50,488H (2.5 mg/kg, s.c.) was assessed using the partition test, in which this drug has been shown to induce anxiolytic-like effects. Further, the effect of daily treatment with U-50,488H for 8 days on ethanol consumption was tested in animals that had consumed ethanol and were subjected during these 8 days to a period of 5 days of interruption of ethanol supply and subsequently to a period of 3 days of renewed access to ethanol. Losers consumed more ethanol than winners. Consumption of ethanol was accompanied by a decrease of anxiety level, as evidenced by an increased approach behaviour in the partition test. U-50,488H stimulated ethanol consu...Continue Reading

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Citations

Aug 19, 2011·Psychopharmacology·Howard C BeckerTamara L Doremus-Fitzwater
Oct 25, 2011·Addiction Biology·Kasia Radwanska, Leszek Kaczmarek
Jul 10, 2010·International Journal of Environmental Research and Public Health·Allison M J Anacker, Andrey E Ryabinin
Jan 22, 2014·Behavioural Brain Research·Cindee F RoblesBrian C Trainor
Apr 21, 2017·Alcoholism, Clinical and Experimental Research·Rachel I Anderson, Howard C Becker
Aug 26, 2018·The European Journal of Neuroscience·Sandra Montagud-RomeroMarta Rodríguez-Arias
Feb 25, 2019·Psychopharmacology·Johannes KornhuberIulia Zoicas
May 18, 2011·Alcoholism, Clinical and Experimental Research·Allison M J AnackerAndrey E Ryabinin
Jun 3, 2021·International Journal of Environmental Research and Public Health·Lucía Sánchez-SalvadorMargarita Moreno
Jul 21, 2021·Biological Psychiatry·Emily L NewmanKlaus A Miczek

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