Anxiety as a predictor of alcohol preference in rats?

Progress in Neuro-psychopharmacology & Biological Psychiatry
Barbara Langen, Heidrun Fink

Abstract

Many clinical studies based on retrospective self-reports indicate a relationship between anxiety and increased alcohol consumption or relapse in individuals with alcohol abuse or dependence. However, by these retrospective studies it cannot be definitely concluded whether the alcohol abuse or the anxiety was first. In the present study, alcohol-consuming behaviour was determined in three rat strains showing different anxiety-related behaviour but being not genetically selected for high or low alcohol consumption. The innate anxiety of the three rat strains (Harlan-Fischer, Wistar-BgVV and Wistar-Harlan) was measured by the elevated plus maze test. Thereafter voluntary ethanol intake was measured for 3 months followed by a progressive ratio paradigm, in which the number of responses required to obtain alcohol was successively increased during session. The point at which rats ceased to respond (breaking point) was taken as a measure of their motivation to obtain ethanol. The study revealed that Harlan-Fischer rats showing most anxiety-related behaviour in the elevated plus maze test displayed the lowest ethanol intake [g/kg/d b.w.] and the lowest breaking points in the progressive ratio paradigm. The Wistar-Harlan rats with leas...Continue Reading

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Citations

Aug 21, 2012·Psychopharmacology·Caroline M HostetlerAndrey E Ryabinin
Apr 28, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Diego CorreiaRoseli Boerngen-Lacerda
Sep 17, 2008·Behavioural Brain Research·Yann PellouxDominique Duterte-Boucher
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·B BertH Fink
Mar 13, 2015·Psychopharmacology·Yann PellouxDominique Duterte-Boucher
Sep 10, 2014·Behavioural Brain Research·Shima Momeni, Erika Roman
Nov 1, 2016·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Dennis D RasmussenJanice C Froehlich
Jan 28, 2015·World Journal of Gastroenterology : WJG·Sabrina L McIlwrath, Karin N Westlund
Sep 28, 2020·Experimental Brain Research·Renata Ferreira Sgobbi, Manoel Jorge Nobre

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