Anxiety behavior, exploratory behavior, and activity in NZB x NZW F1 hybrid mice: role of genotype and autoimmune disease progression

Brain, Behavior, and Immunity
L M Schrott, L S Crnic

Abstract

Behavioral changes often accompany the autoimmune disease systemic lupus erythematosus (SLE) in humans and animals. In a mouse model of SLE, the NZB x NZW F1 (B/W) hybrid, 12-week-old mice display more anxiety behavior, less activity, and less exploratory behavior than non-autoimmune female NZW mice. To determine whether these behaviors result from the autoimmune disease or genetic differences between B/W and NZW mice, they were assessed prior to and during disease emergence (6 and 12 weeks of age, respectively). B/W mice were less active at both ages, suggesting a genetic component to this behavioral difference. Anxiety behavior and exploratory behavior did not differ between B/W and NZW mice at 6 weeks; however, at 12 weeks B/W mice displayed more anxiety behavior and less exploratory behavior, indicating that these behaviors were related with the development of autoimmune disease. Prior experience with these tasks increased anxiety behavior in B/W but not NZW mice, suggesting that B/W mice may be more sensitive to anxiogenic experiences.

Citations

Feb 16, 2013·Brain Research·Sean FoxleyJessy John Alexander
Jan 6, 2009·Journal of Neuroimmunology·Hua-Xin GaoChaim Putterman
Nov 7, 1998·Brain Research·S ZalcmanD M Nance
Mar 15, 2006·Behavioural Brain Research·Aviva KatzavJoab Chapman
Sep 6, 2005·Brain Research. Developmental Brain Research·Kazuhiro NakamuraSachiko Hirose
Aug 21, 2007·Neurochemical Research·Brian E Leonard
Oct 26, 2006·Neurotoxicity Research·B E Leonard, A Myint
May 19, 2019·Arthritis & Rheumatology·Nina KelloBetty Diamond
Mar 28, 2001·Annals of the New York Academy of Sciences·R YirmiyaT Pollmächer
Mar 31, 2021·Current Rheumatology Reports·Aida ZarfeshaniBetty Diamond
Apr 2, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takamasa ChoYoshikatsu Kaneko

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