Jun 10, 2015

Anxiety-related interventions in rodent defense behaviors: systematic review and meta-analyses

BioRxiv : the Preprint Server for Biology
Farhan MohammadAdam Claridge-Chang


Background Assays measuring defense behavior in rodents, including the elevated plus maze, open field and light-dark box assays, have been widely used in preclinical models of anxiety to study the ability of therapeutic interventions to modulate the anxiety-like state. However, many important proposed anxiety-modulating factors, including genes, drugs and stressors have had paradoxical effects in these assays across different studies. Objectives We performed a systematic review and meta-analysis of the literature on the effect of anxiety-targeted interventions on rodent defense behaviors in three commonly-used assays: the elevated plus maze, open field and light-dark box assays. Our aim was to determine the effect sizes of a panel of purported anxiety-related interventions across three assays. Data Sources Using PubMed and EMBASE search phrases to identify articles, a systematic review was conducted on a panel of ten anxiety-linked interventions: diazepam, 5-HT1A receptor knockout and overexpression, SERT knockout and overexpression, pain, restraint, social isolation, corticotropin-releasing hormone and Crhr1. In addition, an ad hoc literature search was used to identify articles studying the effects of two genes that are not r...Continue Reading

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Mentioned in this Paper

Meta Analysis (Statistical Procedure)
CRHR1 gene
CRF receptor type 1
Pre-Clinical Model
Isolation Aspects

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