Anxiogenic effect of corticotropin-releasing hormone in the dorsal periaqueductal grey

Neuroreport
A P MartinsF S Guimarães

Abstract

To investigate whether the dorsal periaqueductal grey (DPAG) might be involved in the anxiogenic effect of intracerebroventricular (i.c.v.) administered corticotropin-releasing hormone (CRH), rats (n = 6-13) received microinjections into the DPAG of CRH (1 or 2 microg) or saline and were tested on the elevated plus maze. The drug caused a dose-dependent decrease in plus maze exploration (percentage of entries into open arms: saline 31.9 +/- 8.6, CRH 1 microg 19.2 +/- 4.0, CRH 2 microg 6.9 +/- 3.7; p < 0.01, ANOVA). In a second experiment the anxiogenic effect of intra-DPAG CRH (2 microg) was prevented by previous microinjection of alpha-helical-CRH(9-41) (0.5 microg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 +/- 3.7, alpha-helical-CRH(9-41) + CRH 45.7 +/- 1.6). These results suggest that the DPAG may be a site of the anxiogenic effect of i.c.v. injected CRH.

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Citations

Nov 25, 2000·Depression and Anxiety·A P MartinsF S Guimarães
Dec 22, 1999·Biological Psychiatry·T Steckler, F Holsboer
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Sep 10, 2009·Neuroreport·Hiroyuki UmegakiAkihisa Iguchi
Jun 26, 2004·Annual Review of Neuroscience·Joshua A Gordon, Rene Hen
Dec 2, 2005·Annual Review of Psychology·E D Leonardo, René Hen
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May 23, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elif Engin, Dallas Treit
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Aug 25, 2004·The Psychiatric Clinics of North America·Asher Simon, Jack Gorman
Apr 23, 2013·Hormones and Behavior·Karina G BorelliMarcus L Brandão
Aug 26, 2014·Psychoneuroendocrinology·Thatiane de Oliveira SergioHélio Zangrossi
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Nov 11, 2006·Behavioural Brain Research·Eduardo F Carvalho-NettoRobert J Blanchard
Aug 28, 2021·International Journal of Molecular Sciences·Tiago ChavesDóra Zelena

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