Anxiolytic and antidepressant effects of ACPA and harmaline co-treatment

Behavioural Brain Research
Mohaddeseh Ebrahimi-GhiriMohammad-Reza Zarrindast

Abstract

Depression and anxiety disorders are among the most common illnesses and a close relationship between them has been found. Because the psychotropic effects and abuse liability of cannabis prevent its therapeutic application in depression and anxiety states, we decided to investigate the effects of the combination of ineffective doses of cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) and β-carbolines on anxiety- and depression-related behaviors in male NMRI mice. Anxiety- and depression-related behaviors were assesses using elevated plus maze (EPM) and forced swim test (FST), respectively. Intraperitoneal administration of ACPA (1 mg/kg) decreased the percentage of time spent in the open-arms (%OAT) and the number of entries to the open-arms (OAE) in the EPM, indicating an anxiogenic-like effect. ACPA also decreased immobility time in the FST compared to the control group, suggesting an antidepressant-like effect. β-carbolines including harmane (5 and 10 mg/kg), norharmane (5 mg/kg) and harmaline (2.5 and 5 mg/kg) produced an anxiogenic-like response, while the highest dose of harmane or harmaline and the middle dose of norharmane induced an antidepressant-like behavior. Furthermore, co-administration of a s...Continue Reading

Citations

Jul 28, 2020·International Journal of Molecular Sciences·Dongchen AnJan Tytgat
Jul 25, 2019·Scientific Reports·Valter T BoldarineEliane B Ribeiro
May 13, 2020·Frontiers in Psychiatry·Francisco NavarreteJorge Manzanares
Jan 10, 2021·Scientific Reports·Renata Mancini BaninMônica Marques Telles
Dec 29, 2020·European Journal of Pharmacology·Yusuf Oloruntoyin AyipoThenmoly Damodaran
Apr 10, 2021·Frontiers in Neuroscience·Jessica MaiuoloVincenzo Mollace

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