Abstract
Escitalopram is a highly selective inhibitor of serotonin re-uptake that is used to treat anxiety disorders. In the present study, we investigated the effects of acute, sub-chronic (14 days) and chronic (21 days) administration of escitalopram (2, 4 and 8 mg/kg, PO) on the performance of rats in the elevated T-maze. For comparison, imipramine (15 mg/kg, PO) was also studied. The apparatus is made of three elevated arms of equal dimension, one enclosed transversal to the two open arms. Inhibitory avoidance of the open arms, trained in the enclosed arm, has been related to generalised anxiety disorder, while one-way escape from one open arm, to panic disorder. After acute administration, the three doses of escitalopram impaired avoidance (anxiolytic effect), while imipramine was ineffective. Escape was unaffected by either drug. With subchronic administration, both drugs were ineffective on either avoidance or escape. After chronic treatment, avoidance was impaired by imipramine and by the two highest doses of escitalopram. In addition, escape was impaired (panicolytic effect) by imipramine and by the highest dose of escitalopram. Locomotion measured in a square arena was increased by the three doses of escitalopram, given chroni...Continue Reading
References
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·F P Zemlan, D L Garver
Aug 1, 1985·Journal of Neuroscience Methods·S PellowM Briley
Aug 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·S L Handley, S Mithani
Jan 1, 1997·Brain Research Bulletin·H Zangrossi, F G Graeff
Jan 12, 1999·Neuroscience and Biobehavioral Reviews·F G GraeffH Zangrossi
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·R C TeixeiraF G Graeff
Nov 13, 2001·Behavioural Brain Research·M C SilveiraF G Graeff
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·H ZangrossiF G Graeff
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Cláudia A JacobRegina L Nogueira
Mar 7, 2003·European Journal of Pharmacology·Connie Sánchez
Apr 1, 2003·CNS Drugs·John Waugh, Karen L Goa
Apr 30, 2003·Psychopharmacology·C SánchezO Wiborg
Jun 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Venessa Beijamini, Roberto Andreatini
Sep 6, 2003·Pharmacology, Biochemistry, and Behavior·Connie SánchezMariusz Papp
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Eric W FishKlaus A Miczek
Dec 9, 2003·The Journal of Clinical Psychiatry·Stephen M StahlDayong Li
Dec 9, 2003·Behavioural Brain Research·Selma Conceição PoltronieriMilena de Barros Viana
Dec 20, 2003·Current Drug Targets. CNS and Neurological Disorders·Martyn D Wood
Apr 27, 2004·L'Encéphale·J-M AzorinP Verpillat
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·Frederico G Graeff
Jul 27, 2004·Depression and Anxiety·Jonathan R T DavidsonHongjie Zheng
Oct 2, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Salim Demétrio JorgeHélio Zangrossi
Dec 21, 2004·Journal of Neurochemistry·Fenghua ChenOve Wiborg
Dec 25, 2004·CNS Spectrums·David J Nutt
Feb 11, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mostafa El MansariNasser Haddjeri
Mar 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Siegfried KasperRico Nil
Jun 29, 2005·Journal of Affective Disorders·Wayne K GoodmanQin Wang
Aug 4, 2005·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Dan J SteinWayne K Goodman
Sep 20, 2005·Behavioural Pharmacology·J M ZanoveliH Zangrossi
Nov 1, 2005·Psychopharmacology·Valquíria Camin de BortoliHélio Zangrossi
Jan 20, 2006·The Journal of Clinical Psychiatry·Jonathan R T DavidsonQin Wang
May 9, 2006·Neuropharmacology·Sandy HoggMaria Jessa
Jan 1, 1991·Journal of Psychopharmacology·J F Deakin, F G Graeff
Citations
Apr 16, 2013·Cell and Tissue Research·Fabrício A MoreiraFrederico G Graeff
Mar 9, 2013·Behavioural Brain Research·Tatiani SorregottiRicardo Luiz Nunes-de-Souza
Mar 19, 2013·Behavioural Brain Research·Christiana Villela de Andrade StraussHelio Zangrossi
Jan 6, 2012·Journal of Psychopharmacology·Holden D BrownMichael E Ragozzino
Sep 26, 2012·Psychopharmacology·Alline Cristina CamposFrancisco Silveira Guimarães
Mar 25, 2014·Neuroscience and Biobehavioral Reviews·Hélio Zangrossi, Frederico G Graeff
Aug 21, 2013·Brain Structure & Function·Xiaoyu ChenGilbert J Kirouac
Jun 12, 2012·International Journal of Radiation Oncology, Biology, Physics·Jobin Kotakkathu VarugheseMorten Lund-Johansen
Nov 9, 2010·Neuroscience and Biobehavioral Reviews·D Caroline BlanchardRobert J Blanchard
Sep 8, 2010·Life Sciences·Vânia R SelaElisabeth A Audi
May 27, 2010·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·J K VarugheseM Lund-Johansen
Mar 8, 2012·Brain Research Bulletin·Laila AsthElaine Cristina Gavioli
Oct 18, 2013·The International Journal of Neuroscience·Paul J Fitzgerald
Apr 5, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Plinio C CasarottoHélio Zangrossi
Mar 25, 2009·The International Journal of Neuropsychopharmacology·Francesca BiggioPaolo Follesa
Nov 27, 2009·Journal of Psychopharmacology·Lucinéia dos SantosFrederico G Graeff
Mar 3, 2009·Journal of Psychopharmacology·C Garcia-LealF S Guimarães
May 23, 2009·Journal of Psychopharmacology·G EsquivelE J Griez
Mar 9, 2019·Molecular Neurobiology·Heloisa Helena Vilela-CostaHélio Zangrossi