Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice

Pharmaceutical Biology
Yi YaoKhalid Rahman

Abstract

In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, and sodium pentobarbital-induced hypnosis tests. Moreover, the acute toxicity of polygalasaponins was also estimated in mice. Sixty minutes after p.o. administration of polygalasaponins (40, 80, 160 mg/kg) in mice, the central crossing counts and percentage of central/total ambulation significantly increased and the number of rearings and defecations was evidently inhibited in the open field test. Polygalasaponins also increased the head-dips of mice in the hole-board test and the time spent by mice in the open arms of the X-maze, prolonged sleep duration and shortened sleep latency in the test of synergetic effect on sodium pentobarbital (45 and 25 mg/kg, respectively). Acute toxic study showed the oral median lethal dose (LD(50)) of polygalasaponins was 3.95 g/kg and 0% lethal dose 2.6 g/kg. These results suggest that polygalasaponin possesses evident anxiolytic and sedative-hypnotic activities and has a relatively safe dose range, which supports the use of Polygala tenuifolia root as an anxiolytic and sed...Continue Reading

References

Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·In-Won ChungYong Sik Kim
Aug 26, 2006·Journal of Ethnopharmacology·E Aguirre-HernándezM Soto-Hernández
Nov 28, 2006·Journal of Ethnopharmacology·Fang HuangChanggui Dou
Feb 3, 2007·The Journal of Pharmacy and Pharmacology·Hong ZhangCheng Peng
Feb 13, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tingli LiChunyu Sun
Dec 22, 2007·Pharmacology, Biochemistry, and Behavior·Nima NaderiFereshteh Motamedi
Feb 22, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hong ZhangCheng Peng
Aug 1, 1997·Archives of Pharmacal Research·K J JangH C Kim

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Citations

May 28, 2011·Biomedical Chromatography : BMC·Yun LingChenggang Huang
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Betty Yuen Kwan LawVincent Kam Wai Wong
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Apr 3, 2020·Chinese Journal of Integrative Medicine·Xiao-Juan RenZhi-Peng Peng
Jun 2, 2020·Phytotherapy Research : PTR·Muqeet WahidMuhammad Hassham Hassan Bin Asad
Feb 28, 2020·Experimental and Therapeutic Medicine·Zi-Wen ChenFu-Ping Xu
Dec 28, 2019·Molecular Brain·Vinicius M Gadotti, Gerald W Zamponi
May 1, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sheng WangHui-Yong Huang
Sep 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Julia FedotovaPeter Kruzliak
Jun 2, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wu ZengBetty Yuen Kwan Law
Jun 20, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dan-Tong ZhaoRong Rong

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