Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

Phytotherapy Research : PTR
Flávia Cristina Fernandes PimentaReinaldo Nóbrega de Almeida

Abstract

The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML.

References

Jun 1, 1970·Journal of Consulting and Clinical Psychology·G J Allen
Nov 22, 2002·The American Journal of Hospice & Palliative Care·Margaret Louis, Susan D Kowalski
Aug 12, 2004·Planta medica·T Hongratanaworakit, G Buchbauer
Sep 29, 2005·Journal of Pediatric Hematology/oncology·Sven GottschlingNorbert Graf
Oct 29, 2005·Life Sciences·Aline de Moraes PultriniMirtes Costa
Jul 31, 2007·Lancet·Rüdiger HehlmannUNKNOWN European LeukemiaNet
Aug 9, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Arinobu Tojo
Jul 1, 2003·Journal of the National Comprehensive Cancer Network : JNCCN·Jana PortnowStuart A Grossman
Feb 16, 2011·Journal of Clinical Nursing·Sarah Watmough, Maria Flynn
Nov 9, 2011·Revista brasileira de anestesiologia·Mahmood AkhlaghiMohsen Akhlaghi
Dec 12, 2012·Journal of Affective Disorders·Mari Lloyd-WilliamsChris Shiels
Dec 12, 2012·Pain Research and Treatment·Sarah K GallowayJeffrey Borckardt
Jul 30, 2014·Iranian Red Crescent Medical Journal·Masoumeh NamaziSharareh Jannesari
Dec 2, 2014·Pediatric Clinics of North America·Nobuko HijiyaMeinolf Suttorp

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Citations

Jun 19, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Farhad MoslemiMohammad Reza Heidari
Jul 7, 2018·International Journal of Molecular Sciences·Noura S Dosoky, William N Setzer
Jan 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Carmen MannucciGioacchino Calapai
Sep 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Laura RombolàLuigi Antonio Morrone
Dec 31, 2019·BioMed Research International·Rui WangOmer Iqbal
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Gabriel Chaves NetoMargareth de Fátima Formiga Melo Diniz
Jun 2, 2018·Oxidative Medicine and Cellular Longevity·Ipek SuntarLuca Rastrelli
Jul 16, 2020·Journal of Affective Disorders·Minmin GongFuer Lu
Jun 12, 2021·Planta medica·Silvia BorrásJosé Luis Ríos

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