Anxiolytic effects of ascorbic acid and ketamine in mice

Journal of Psychiatric Research
Daiane B FragaAna Lúcia S Rodrigues

Abstract

Some studies have demonstrated that ascorbic acid, similarly to ketamine, exhibits antidepressant-like effects mediated, at least in part, by modulation of the glutamatergic system. Despite the involvement of glutamatergic system in the pathophysiology of anxiety disorders, the ability of ascorbic acid and ketamine to elicit anxiolytic effects in animal models remains to be established. Therefore, this study investigated the effects of a single administration of ascorbic acid, ketamine or diazepam (positive control) in different animal models of anxiety. Mice were treated with ascorbic acid (1, 3 and 10 mg∕kg, p.o.), ketamine (1 and 10 mg∕kg, i.p.) or diazepam (2 mg∕kg, p.o) and their behavioral responses were assessed in the elevated plus maze, open field test (OFT), ligh∕dark preference test and marble burying test. Ascorbic acid increased total time spent in the open arms of elevated plus maze, increased total time in the center of the OFT, decreased rearing responses, increased the latency to grooming, decreased the rostral grooming, but did not affect body grooming. Furthermore, ascorbic acid increased the latency time and total time in light area in the ligh∕dark preference test, but did not affect the performance of mice...Continue Reading

Citations

Jan 14, 2020·Psychopharmacology·Summer L ThompsonStephanie C Dulawa
Sep 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin ChenHeyuan Jiang
Jun 9, 2020·Frontiers in Behavioral Neuroscience·Greer McKendrickNicholas M Graziane
Jan 27, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gabriela P SiloteVanessa Beijamini
Mar 6, 2021·Experimental Brain Research·Ahmad Mohammadi-FaraniReza Rahimian
Mar 14, 2021·Purinergic Signalling·Priscila B RosaAna Lúcia S Rodrigues
Aug 4, 2020·The Journal of Nutritional Biochemistry·Bettina MoritzMauricio P Cunha
Mar 22, 2021·Biological Trace Element Research·Noreen SamadImran Imran
Apr 1, 2021·Life Sciences·Máira Tereza Talma ChíricoRodrigo Cunha Alvim de Menezes
Jul 17, 2021·Neural Regeneration Research·Carlos Pereira MartinsRafael Cypriano Dutra
Nov 14, 2020·Clinical Nutrition ESPEN·Hossein FarhadnejadAzita Hekmatdoost

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