PMID: 1983352Sep 1, 1990Paper

Anxiolytic-like action of DuP753, a non-peptide angiotensin II receptor antagonist

N M BarnesR J Naylor


The potential of DuP753, an angiotensin II receptor antagonist, to inhibit the suppressed behaviour of mice in a light/dark aversion test was investigated. The aversive response to the light compartment of the apparatus was reduced (increase in latency to move from the light to the dark compartment and decreases in rears, line crossings and percentage of time spent in the dark compartment) following treatment with DuP753 (0.1-1000 micrograms kg-1 p.o., 45 min before the test). These results further implicate the modulation of mental function by angiotensin II.


May 1, 1993·Medicinal Research Reviews·R M Pinder, J H Wieringa
Jul 21, 1992·European Journal of Pharmacology·N M BarnesR J Naylor
Jan 19, 1993·European Journal of Pharmacology·J M BarnesN M Barnes
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·M J WaynerJ B Denny
Mar 22, 2002·European Journal of Pharmacology·Paul R Gard
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·P R GardC A Warrington
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·D Georgieva, V Georgiev
Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juan M SaavedraEnrique Sanchez-Lemus
Dec 1, 1991·British Journal of Pharmacology·K F SongF A Mendelsohn
Mar 24, 2006·Cell and Tissue Research·O von Bohlen und Halbach, D Albrecht
Nov 24, 2005·Clinical and Experimental Hypertension : CHE·Jan J Braszko
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F MudersK Jandeleit-Dahm
Sep 11, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Hui-Lin Pan
Apr 8, 2006·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Juan M SaavedraJin Zhou

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