Anxiolytic-like and sedative actions of Rollinia mucosa: possible involvement of the GABA/benzodiazepine receptor complex

Pharmaceutical Biology
Rosa Estrada-ReyesMariano Martínez-Vázquez

Abstract

This study evaluated possible CNS effects of a hexane extract of leaves from Rollinia mucosa (Jacq.) Baill. (Annonaceae). This plant extract induced anxiolytic-like actions similar to those induced by diazepam in the avoidance exploratory behavior paradigm. Its significant activity was shown at doses from 1.62 to 6.25 mg/kg. It also enhanced pentobarbital-induced hypnosis time, and at high doses produced motor coordination impairment. The benzodiazepine (BDZ) receptor binding, evaluated by in vitro autoradiography following a single administration of R. mucosa, revealed that this plant extract reduced BDZ binding in the hippocampus (29%), amygdala (26%), and temporal cortex of mice (36%). In conclusion, the present findings support the proposal that R. mucosa may induce central nervous system (CNS) depressant effects, presumably through an interaction with the GABA/benzodiazepine receptor complex.

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Citations

Jan 25, 2014·Journal of Ethnopharmacology·Rosa Estrada-ReyesMariano Martínez-Vázquez
Mar 30, 2016·Journal of Ethnopharmacology·Carolina López-Rubalcava, Erika Estrada-Camarena
Apr 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Md MoniruzzamanAfia Ferdous
Jul 15, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Md MoniruzzamanMd Sarwar Hossain
Apr 17, 2018·Journal of Receptor and Signal Transduction Research·Ganesan Mahendran, Ramachandran Vijayan
Feb 15, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Md AnisuzzmanSinthia Rahman
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Esra Küpeli AkkolEduardo Sobarzo-Sánchez
Sep 21, 2017·Medicines·Kenneth LundstromLong Doan Dinh
Oct 21, 2018·BMC Complementary and Alternative Medicine·Md MoniruzzamanMirola Afroze
Aug 18, 2021·Food Research International·Nayara Macêdo Peixoto AraujoGlaucia Maria Pastore

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