PMID: 22580520May 15, 2012Paper

Anxiolytic-like effect of losartan injected into amygdala of the acutely stressed rats

Pharmacological Reports : PR
Luis H Llano LópezPascual A Gargiulo

Abstract

It has been recognized that the stress-related peptides are involved in anxiety states. Angiotensin II receptor blockade by systemic administration of the AT(1) receptor antagonists has been proposed as a new treatment possibility for anxiety disorders. For better understanding of the related mechanisms, in this study we evaluated effects of bilateral intraamygdaloid injections of 2 (LOS 2) and 4 (LOS 4) μg of losartan (LOS), a selective AT(1) receptor antagonist, on the behavior of the not stressed and acutely stressed rats in an elevated "plus" maze. Under non-stress conditions, LOS 4 increased time spent in the open arms (p < 0.01), number of extreme open arm arrivals (p < 0.05), time per entry (p < 0.01), and the number of total arm entries (p < 0.05) showing thus considerable anxiolytic activity. The open arm extreme arrivals were increased by LOS 4 in both not stressed (p < 0.05) and stressed (p < 0.05) rats. When no stressed and stressed LOS 4 animals were compared, time per entry and the number of closed arm entries (p < 0.05, both) were decreased in the latter group. Moreover, the LOS 4 stressed rats had significantly increased open/closed arm quotient (p < 0.05) as compared to the both control and LOS 4 non-stress gro...Continue Reading

Associated Clinical Trials

Mar 15, 2016·Murray B. Stein, Murray B. Stein

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Citations

Oct 8, 2013·Biological Psychiatry·Paul J MarvarKerry J Ressler
Jul 31, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anjana Bali, Amteshwar Singh Jaggi
Jan 21, 2015·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Omamuyovwi Meashack IjomonePolycarp Umunna Nwoha
Jul 9, 2014·BioMed Research International·Maria de los Angeles MarinzaldaGustavo Baiardi
Dec 17, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Anjana BaliAmteshwar Singh Jaggi
Oct 28, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lorika ShkreliAndrea Reinecke
Jul 1, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Luis H Llano LópezPascual A Gargiulo
Apr 30, 2016·Clinical Science·Ana Flávia Almeida-SantosMaria José Campagnole-Santos
Aug 2, 2017·BMC Medicine·João VianBrisa S Fernandes
Jun 16, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Augusto P I GargiuloPascual A Gargiulo
May 21, 2021·Drug and Chemical Toxicology·Omamuyovwi M IjomoneAzubuike P Ebokaiwe
Jan 14, 2020·Neuropsychobiology·Augusto P I GargiuloPascual Ángel Gargiulo

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