PMID: 22358103Feb 24, 2012Paper

Anxiolytic-like effects of olanzapine, risperidone and fluoxetine in the elevated plus-maze test in rats

Pharmacological Reports : PR
Z Rogóz, G Skuza

Abstract

In the present study was examined the effect of treatment with olanzapine or risperidone, given separately or in combination with fluoxetine, in the elevated plus-maze test (an animal model of anxiety) in male Wistar rats. The obtained results showed that treatment with olanzapine (1 mg/kg), risperidone (0.1 and 0.3 mg/kg) or fluoxetine (5 and 10 mg/kg) induced an anxiolytic-like effect in the elevated plus-maze test. Olanzapine, risperidone and fluoxetine, tested in doses effective in the model of anxiolytic-like actions, did not affect motor coordination, while olanzapine (3 mg/kg) and risperidone (0.3 mg/kg) produced a significant reduction of exploratory activity in the open field test. In a combination study, the anxiolytic-like effect of olanzapine or risperidone was significantly antagonized by co-treatment with fluoxetine. Additionally, co-treatment with olanzapine or risperidone and fluoxetine disturbed the motor coordination of rats in a rota-rod test. These findings indicate that olanzapine, risperidone and fluoxetine per se may be clinically effective in treating anxiety disorders, but their effects may be attenuated when they are used in combination with other medications.

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Citations

Oct 21, 2014·BioMed Research International·Carlos M ContrerasBlandina Bernal-Morales
Oct 4, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Maurice Y F ShenSusan R George
Jun 6, 2015·Pharmacology, Biochemistry, and Behavior·Nallely García-CárdenasAlonso Fernández-Guasti
Apr 14, 2016·Pharmacology Research & Perspectives·Abdelkader Ennaceur, Paul L Chazot
Sep 15, 2015·Stress : the International Journal on the Biology of Stress·R M AbuhamdahA Ennaceur
Jul 19, 2013·TheScientificWorldJournal·Ana G Gutiérrez-GarcíaDiana Idania Vásquez-Hernández
May 12, 2015·Pharmacology, Biochemistry, and Behavior·Thomas R MorrisonRichard H Melloni
Apr 19, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rodrigo PascualCarlos Bustamante
Nov 3, 2016·Acta Neuropsychiatrica·Masayo OhyamaTsukasa Koyama
Oct 17, 2015·PloS One·Renan IdalencioLeonardo José Gil Barcellos
Apr 24, 2019·Journal of Psychopharmacology·Susana Barbosa Méndez, Alberto Salazar-Juárez
Dec 19, 2020·Neurotoxicity Research·Adam WojtasKrystyna Gołembiowska
May 26, 2021·Psychopharmacology·Monika HerianKrystyna Gołembiowska

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