Abstract
In the present study was examined the effect of treatment with olanzapine or risperidone, given separately or in combination with fluoxetine, in the elevated plus-maze test (an animal model of anxiety) in male Wistar rats. The obtained results showed that treatment with olanzapine (1 mg/kg), risperidone (0.1 and 0.3 mg/kg) or fluoxetine (5 and 10 mg/kg) induced an anxiolytic-like effect in the elevated plus-maze test. Olanzapine, risperidone and fluoxetine, tested in doses effective in the model of anxiolytic-like actions, did not affect motor coordination, while olanzapine (3 mg/kg) and risperidone (0.3 mg/kg) produced a significant reduction of exploratory activity in the open field test. In a combination study, the anxiolytic-like effect of olanzapine or risperidone was significantly antagonized by co-treatment with fluoxetine. Additionally, co-treatment with olanzapine or risperidone and fluoxetine disturbed the motor coordination of rats in a rota-rod test. These findings indicate that olanzapine, risperidone and fluoxetine per se may be clinically effective in treating anxiety disorders, but their effects may be attenuated when they are used in combination with other medications.
References
Jul 10, 1992·Journal of Medicinal Chemistry·N J HribA M Szczepanik
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·S Pellow, S E File
Jun 1, 1996·The American Journal of Psychiatry·M B Hamner
Mar 1, 1997·The Journal of Clinical Psychiatry·D J SteinR A Emsley
Apr 1, 1994·Behavioural Pharmacology·N.A. MooreN.C. Tye
Jul 19, 2001·International Clinical Psychopharmacology·M I ButterfieldJ R Davidson
Nov 20, 2001·International Clinical Psychopharmacology·F PettyK A Young
Dec 20, 2002·International Clinical Psychopharmacology·M B HamnerG W Arana
Mar 18, 2003·Journal of Clinical Psychopharmacology·Edward P MonnellyTerence Keane
Oct 28, 2004·European Journal of Pharmacology·Junichi MiyamotoTeruhiko Matsumiya
Dec 24, 2005·Harvard Review of Psychiatry·Nora Selengut BrookeCarl Salzman
May 16, 2006·Behavioural Brain Research·Tim KarlIrina Dedova
Jan 15, 2008·Acta Psychiatrica Scandinavica·Richard C Shelton, George I Papakostas
Jul 1, 2008·Journal of Psychiatric Research·Gabor I KeitnerMartin B Keller
Sep 10, 2008·Neuroscience Letters·Ashish Dhir, S K Kulkarni
Jul 11, 2009·Neuropsychiatric Disease and Treatment·William V Bobo, Richard C Shelton
Jan 19, 2010·Pharmacological Reports : PR·Zofia Rogóz
Feb 20, 2010·Pharmacology, Biochemistry, and Behavior·Tao SunMing Li
May 24, 2011·Pharmacological Reports : PR·Elżbieta NowakowskaCzesław Sadowski
Oct 18, 2011·Pharmacological Reports : PR·Anna PartykaGabriel Nowak
Citations
Oct 21, 2014·BioMed Research International·Carlos M ContrerasBlandina Bernal-Morales
Aug 21, 2013·Pharmacological Reports : PR·Luis H Llano LópezPascual A Gargiulo
Oct 4, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Maurice Y F ShenSusan R George
Jun 6, 2015·Pharmacology, Biochemistry, and Behavior·Nallely García-CárdenasAlonso Fernández-Guasti
Apr 14, 2016·Pharmacology Research & Perspectives·Abdelkader Ennaceur, Paul L Chazot
Sep 15, 2015·Stress : the International Journal on the Biology of Stress·R M AbuhamdahA Ennaceur
Jul 19, 2013·TheScientificWorldJournal·Ana G Gutiérrez-GarcíaDiana Idania Vásquez-Hernández
May 12, 2015·Pharmacology, Biochemistry, and Behavior·Thomas R MorrisonRichard H Melloni
Apr 19, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rodrigo PascualCarlos Bustamante
Nov 3, 2016·Acta Neuropsychiatrica·Masayo OhyamaTsukasa Koyama
Mar 19, 2015·PloS One·Jean Luc do RegoHubert Vaudry
Oct 17, 2015·PloS One·Renan IdalencioLeonardo José Gil Barcellos
Apr 24, 2019·Journal of Psychopharmacology·Susana Barbosa Méndez, Alberto Salazar-Juárez
Feb 23, 2020·Psychopharmacology·Magdalena BiałońAgnieszka Wąsik
Aug 16, 2016·Oxidative Medicine and Cellular Longevity·Min HuXiao-Qing Tang
Dec 19, 2020·Neurotoxicity Research·Adam WojtasKrystyna Gołembiowska
Nov 16, 2020·Physiology & Behavior·Christen N SnyderDeanne Buffalari
Feb 2, 2021·Frontiers in Nutrition·Imran ImranFaten Abdullah Alaqil
Aug 25, 2020·Behavioural Brain Research·Paloma T BirmannLucielli Savegnago
Apr 24, 2021·Psychopharmacology·Habiba Rashid, Touqeer Ahmed
May 26, 2021·Psychopharmacology·Monika HerianKrystyna Gołembiowska
Jul 3, 2021·Neuropsychiatric Disease and Treatment·Anna WesołowskaAnna Partyka
Sep 18, 2014·Learning & Memory·Ana Rita SantosClaudia Bagni