Anxious distress in depressed outpatients: Prevalence, comorbidity, and incremental validity

Journal of Psychiatric Research
Anthony J RoselliniTimothy A Brown

Abstract

The goals of this study were to estimate the prevalence of the DSM-5 anxious distress specifier (AD) among depressed outpatients, to examine associations of AD with comorbid diagnoses, and to test the incremental validity of AD over comorbidity in predicting functional impairment and severity of anxiety and depression symptoms. The sample was 237 outpatients diagnosed with major depressive disorder (MDD) or persistent depressive disorder (PDD), with and without AD, using the Anxiety and Related Disorders Interview Schedule for DSM-5. Outpatients also completed self-report questionnaires assessing functional impairment and anxiety, stress, and depression symptom severity. Two-by-two contingency tables were used to examine the associations of AD with comorbidity. Two-thirds (66.2%) of outpatients were assigned AD, with similar rates among those with MDD and PDD. Outpatients with AD were significantly more likely than those without AD to have a comorbid GAD diagnosis (OR = 2.47). Hierarchical multiple regressions were used to test the incremental validity of AD in predicting functional impairment and symptom outcomes beyond comorbid disorders. Controlling for comorbid disorders, AD was significantly associated with more severe fun...Continue Reading

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Citations

May 22, 2020·International Review of Psychiatry·Koen Demyttenaere, Elke Heirman
Aug 29, 2019·Journal of Neural Transmission·Isabelle HäberlingGregor Berger
Oct 30, 2021·International Journal of Methods in Psychiatric Research·Ching-I HungChing-Hui Yang

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