Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation.

Trends in Genetics : TIG
Niels H Gehring, Jean-Yves Roignant

Abstract

Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene expression. The identification of the actual splice sites and the proper removal of introns are essential for the production of the desired mRNA isoforms and their encoded proteins. While the basic mechanisms of splicing regulation are well understood, recent work has uncovered a growing number of noncanonical splicing mechanisms that play key roles in the regulation of gene expression. In this review, we summarize the current principles of splicing regulation, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, transcription, and RNA modifications. We further discuss the recent development of emerging splicing mechanisms, such as recursive and back splicing, and their impact on gene expression.

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Citations

Feb 7, 2021·International Journal of Molecular Sciences·Flora Brozzi, Romano Regazzi
Mar 7, 2021·Biomolecules·Charles W Carter, Peter R Wills
May 2, 2021·Trends in Genetics : TIG·Václav BrázdaRichard P Bowater
Jun 23, 2021·Nucleic Acids Research·Nadine KörtelKathi Zarnack

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