Aorta calcification burden: Towards an integrative predictor of cardiac outcome after transcatheter aortic valve implantation

Atherosclerosis
Brahim HarbaouiPierre Lantelme

Abstract

The principal objective was to determine the effect of total aortic calcification (TAC) burden on outcomes (cardiac mortality, all-cause mortality, and heart failure (HF)) after transcatheter aortic valve implantation (TAVI). The secondary aim was to assess the contribution of each segment of the aorta to these outcomes. Indications for TAVI are increasing in number. Even after procedural success, however, some patients die soon afterwards, indicating the futility of TAVI in certain cases. Aortic calcifications were measured on computed tomography in 164 patients treated by TAVI. TAC, ascending aortic calcification (AsAC), descending aorta calcifications, and abdominal aorta calcifications were expressed as tertiles and their prognostic values were assessed in a multivariable cox analysis adjusted for major confounders including EuroSCORE. Median duration of follow-up was 565 (interquartile range: 246 to 1000) days. TAC (tertile3 vs. tertile1) was significantly and strongly associated with cardiac mortality (hazard ratio [HR]: 16.74; 95% confidence interval [CI]: 2.21 to 127.05; p = 0.006) and all-cause mortality (HR: 2.39; 95% CI: 1.18 to 4.84; p = 0.015) but not with HF (HR: 1.84; 95% CI: 0.87 to 3.90; p = 0.110). Each segmen...Continue Reading

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Citations

Jan 14, 2021·Journal of the American Heart Association·Kevin LeowJoshua R Lewis
Oct 8, 2018·Journal of Vascular Surgery·Matthew J TerBushMichael C Stoner
Mar 12, 2021·European Heart Journal Cardiovascular Imaging·Brahim HarbaouiPierre Lantelme
Apr 23, 2020·The American Journal of Cardiology·Clément BèclePierre Lantelme
Jul 6, 2020·The American Journal of Cardiology·Pierre LantelmeLaurent Fauchier
Oct 28, 2019·Annales de cardiologie et d'angéiologie·P Lantelme, B Harbaoui
Aug 29, 2019·International Journal of Cardiology·Brahim HarbaouiPierre Lantelme
May 13, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christopher J BroydMichael Mullen

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