Aortic-Brachial Pulse Wave Velocity Ratio: A Measure of Arterial Stiffness Gradient Not Affected by Mean Arterial Pressure

Pulse
Catherine FortierMohsen Agharazii

Abstract

Aortic stiffness, measured by carotid-femoral pulse wave velocity (cf-PWV), is used for the prediction of cardiovascular risk. This mini-review describes the nonlinear relationship between cf-PWV and operational blood pressure, presents the proposed methods to adjust for this relationship, and discusses a potential place for aortic-brachial PWV ratio (a measure of arterial stiffness gradient) as a blood pressure-independent measure of vascular aging. PWV is inherently dependent on the operational blood pressure. In cross-sectional studies, PWV adjustment for mean arterial pressure (MAP) is preferred, but still remains a nonoptimal approach, as the relationship between PWV and blood pressure is nonlinear and varies considerably among individuals due to heterogeneity in genetic background, vascular tone, and vascular remodeling. Extrapolations from the blood pressure-independent stiffness parameter β (β0) have led to the creation of stiffness index β, which can be used for local stiffness. A similar approach has been used for cardio-ankle PWV to generate a blood pressure-independent cardio-ankle vascular index (CAVI). It was recently demonstrated that stiffness index β and CAVI remain slightly blood pressure-dependent, and a more...Continue Reading

References

Jan 1, 1980·Journal of Biomechanics·K HayashiK Moritake
Feb 9, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A CattellP S Hasleton
May 11, 1999·Circulation·J BlacherG M London
Jul 2, 2003·Diabetes Care·James D CameronChakravarthi Rajkumar
May 1, 1964·Circulation Research·H WOLINSKY, S GLAGOV
Nov 1, 2005·Journal of the American College of Cardiology·Carmel M McEnieryUNKNOWN ACCT Investigators
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Carmel M McEnieryAlbert P Avolio
Feb 5, 2008·Diabetes Research and Clinical Practice·Junko IbataKishio Nanjo
Mar 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Keijiro NakamuraHirofumi Noike
Dec 9, 2008·Journal of Atherosclerosis and Thrombosis·Tsuneo TakenakaHiromichi Suzuki
Mar 23, 2011·Angiology·Shigeo HorinakaToshihiko Ishimitsu
Jun 2, 2011·Journal of Atherosclerosis and Thrombosis·Kohji ShiraiMasanobu Takata
Jun 10, 2011·American Journal of Hypertension·Takashi TarumiAndreana P Haley
Nov 8, 2014·Journal of Hypertension·Bart SpronckKoen D Reesink
Dec 3, 2014·Hypertension·Catherine FortierMohsen Agharazii
Apr 2, 2016·Journal of Hypertension·Dean S PiconeJames E Sharman
Aug 19, 2016·Vascular Health and Risk Management·Kazuhiro ShimizuKohji Shirai
Jan 20, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Daniel BiaEdmundo Cabrera-Fischer
Mar 24, 2017·Journal of Atherosclerosis and Thrombosis·Tomoyuki YamamotoKohji Shirai

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Citations

Jun 22, 2019·The Journal of Clinical Hypertension·Alessandro MalobertiCristina Giannattasio
Dec 12, 2019·Frontiers in Cardiovascular Medicine·Rachel E ClimieRosa Maria Bruno
Jun 27, 2020·Environmental Health Perspectives·Carmen de KeijzerPayam Dadvand

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