Aortic coarctation induces oxidative stress in rat tissues

Life Sciences
Ariel H PolizioClara Peña

Abstract

The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels of reduced glutathione (48%), lipid peroxidation (148%) and activation of superoxide dismutase and glutathione peroxidase (189% and 37%, respectively), compared with controls. Other oxidative stress indicators were also altered in erythrocytes from Coa rats: increased protein carbonyl content (141%) and total glutathione level (349%) were determined. Inactivation of the antioxidant enzymes catalase (27%), superoxide dismutase (58%) and glutathione peroxidase (25%) was observed in erythrocytes from the Coa group. Taken jointly our results provide strong evidence for the production of oxidative stress in heart and erythrocytes from aortic coarcted rats.

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Citations

Dec 23, 2006·Antioxidants & Redox Signaling·Ariel H Polizio, Clara Peña
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ariel H PolizioMaria L Tomaro
Nov 3, 2010·The American Journal of the Medical Sciences·Chuangjia HuYanyan Li

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