Aortic Dissection and Cardiac Dysfunction Emerged Coincidentally During the Long-Term Treatment with Angiogenesis Inhibitors for Metastatic Renal Cell Carcinoma

International Heart Journal
Midori TakadaMasashi Fujita

Abstract

Angiogenesis inhibitors, such as sorafenib and axitinib, which target vascular endothelial growth factor (VEGF) signaling, are widely used for renal cell carcinoma, including metastasis. In this study, we report a case of cardiovascular adverse events of aortic dissection and cardiac dysfunction during treatment with sorafenib and axitinib for metastatic renal cell carcinoma. A 66-year-old man had been administered sorafenib for 2 years after nephrectomy due to renal cell carcinoma. To control the progression of metastatic lung tumor, axitinib was started after sorafenib for four years. During the treatment, angiotensin II type 1 receptor blockers and Ca antagonists were used to strictly control the axitinib-induced hypertension and proteinuria. Aortic dissection and cardiac dysfunction occurred coincidentally. Considering the critical role of VEGF signaling in the homeostasis of the cardiovascular system, we speculated that the long-term use of axitinib and sorafenib directly influenced the initiation of aortic dissection and cardiac dysfunction. Although the precise mechanisms underlying the aortic dissection and cardiac dysfunction induced by angiogenesis inhibition are still elusive, onco-cardiologists and oncologists shoul...Continue Reading

References

Aug 1, 1993·The American Journal of Physiology·D D KuT A Brock
Mar 19, 2003·Circulation·Timothy D HenryUNKNOWN VIVA Investigators
Jun 5, 2004·The Oncologist·Napoleone Ferrara
Nov 3, 2007·The Journal of Clinical Investigation·Joerg HeinekeJeffery D Molkentin
Dec 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-J MouradB I Levy
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neeltje SteeghsEelco de Koning
Sep 9, 2009·Nature Reviews. Clinical Oncology·S Percy IvyBennett M Kaufman
Oct 27, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N SteeghsH Gelderblom
Oct 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SerranoJ Carles
Oct 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J EdelineJ-J Patard
Nov 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mary Jo Mulligan-Kehoe
Nov 9, 2012·Circulation·Tomohiro KuriharaYasunori Okada
Dec 20, 2012·Circulation Research·Ying H ShenScott A LeMaire
Aug 31, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Juan Carlos PlanaPatrizio Lancellotti
Oct 30, 2014·São Paulo Medical Journal = Revista Paulista De Medicina·Maria Nirvana da Cruz Formiga, Marcello Ferretti Fanelli
Mar 17, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bart SpronckKoen D Reesink
Oct 3, 2017·International Heart Journal·Manami KatohIssei Komuro

❮ Previous
Next ❯

Citations

Sep 19, 2018·Journal of Atherosclerosis and Thrombosis·Mikio MukaiToru Oka
Mar 27, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Ying H ShenHong S Lu
Apr 16, 2021·British Journal of Clinical Pharmacology·Jeresa I A WillemsDaan J L van Twist
Dec 3, 2021·International Heart Journal·Haruka YokoyamaYasushi Fujio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
F C S EngJ J Knox
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Brian I RiniJanice P Dutcher
© 2022 Meta ULC. All rights reserved