Aortic Hemostasis and Resuscitation: Preliminary Experiments Using Selective Aortic Arch Perfusion With Oxygenated Blood and Intra-aortic Calcium Coadministration in a Model of Hemorrhage-induced Traumatic Cardiac Arrest

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
James E ManningNicholas A True

Abstract

Selective aortic arch perfusion (SAAP) uses a thoracic aortic balloon occlusion catheter for heart and brain perfusion in cardiac arrest to achieve return of spontaneous circulation (ROSC). SAAP with oxygenated stored blood was studied in a model of hemorrhage-induced cardiac arrest. The study hypothesis was that intra-aortic calcium coadministration would be required to maintain normal aortic arch blood ionized calcium during SAAP and to achieve ROSC. Twelve anesthetized, domestic swine underwent severe hemorrhage and liver injury resulting in cardiac arrest. Whole blood and packed red blood cells (RBCs) stored in citrate anticoagulant served as perfusates for SAAP. Experiments were performed with four combinations of SAAP with oxygenated stored blood and intra-aortic calcium gluconate infusion: 1) whole blood without calcium, 2) whole blood with calcium, 3) lactated Ringers-diluted packed RBCs with calcium, and 4) normal saline-diluted packed RBCs with calcium. Aortic arch blood ionized calcium was monitored. Occurrence of ventricular dysrhythmias, success rate for ROSC, and the need for simultaneous intra-aortic calcium infusion were assessed. Selective aortic arch perfusion using whole blood without intra-aortic calcium (n ...Continue Reading

References

Oct 1, 1976·British Journal of Anaesthesia·J K DenlingerJ H Lecky
Sep 11, 1992·Annals of Emergency Medicine·J E ManningE A Norfleet
Feb 1, 1992·Critical Care Medicine·G P Zaloga
Sep 26, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J E ManningE A Norfleet
Jan 12, 2007·The Journal of Trauma·Homer C TienFrederick D Brenneman
May 18, 2012·The Journal of Surgical Research·Jonathan J MorrisonTodd E Rasmussen
Dec 5, 2012·The Journal of Trauma and Acute Care Surgery·Brian J EastridgeLorne H Blackbourne

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Citations

Oct 11, 2017·The Journal of Trauma and Acute Care Surgery·Anders J DavidsonUNKNOWN BEST Study Group
Nov 3, 2016·Current Opinion in Critical Care·Zane B PerkinsKarim Brohi
May 14, 2016·Shock·Rachel M RussoTimothy K Williams
Apr 30, 2020·The Journal of Trauma and Acute Care Surgery·James E ManningJeremy W Cannon
Dec 22, 2017·The Journal of Trauma and Acute Care Surgery·Anders J DavidsonUNKNOWN BEST Study Group
Sep 15, 2020·Shock·Marta J MadurskaJonathan J Morrison
Jul 15, 2021·Critical Care Medicine·Heidi J DaltonRobert H Bartlett

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