PMID: 6704051Mar 1, 1984Paper

Aortic intimal response to endothelial removal in cebus and squirrel monkeys

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
G A Hoover, K C Hayes

Abstract

Whereas squirrel monkeys have an inherent susceptibility to atherosclerosis, cebus monkeys are relatively resistant. To assess whether this difference might lie in their response to endothelial injury, the acute morphologic changes in the aortic intima after endothelial removal were examined in the two species. The endothelium of the lower thoracic aorta was removed with an embolectomy catheter, and the intimal response was compared with the uninjured upper thoracic aorta in each monkey. By 21 days after aortic denudation, regrowth of the endothelium (assessed by in vivo Evans' blue dye staining) was significantly greater in squirrel monkeys (90% +/- 5% of aortic surface) than in cebus (56% +/- 11%). Squirrel monkeys had comparable sudanophilic surface in the nonballooned, control aorta (25% +/- 7%) and the ballooned, lower thoracic segment (17% +/- 6%). Cebus monkey aortas had no sudanophilia in either segment. The intima/media ratios (IMR) in all regions of the aorta were significantly greater in squirrel monkeys than in cebus, but in both species the IMR of the ventral ballooned segment was two to three times the IMR of the nonballooned control segment. In the dorsal aorta, where endothelial regrowth was more rapid, the IMR ...Continue Reading

References

Oct 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·R J NicolosiK C Hayes
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S H Blose
Apr 1, 1975·Experimental and Molecular Pathology·B C BullockH B Lofland
Feb 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L L Muller, T J Jacks
Oct 1, 1972·The Journal of Experimental Medicine·M B Stemerman, R R Ross
Aug 1, 1967·Canadian Journal of Psychology·H Wells, K Deffenbacher
Jul 1, 1969·Acta Oto-laryngologica·M Igarashi, T Kanda
Sep 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R Ross
May 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M A ReidyS M Schwartz
May 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G A HooverK C Hayes
Oct 1, 1964·The Journal of Cell Biology·E R WEIBEL, G E PALADE

Citations

Feb 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K C Hayes, A Pronczuk
Sep 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L M AldersonR J Nicolosi
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A K VerheyenM J Borgers

Related Concepts

Scarlet Red Topical Ointment
Descending Aorta
Arteriosclerosis
Azo Compounds
Catheterization
Capuchin Monkey
Disease Susceptibility
Endothelium
Lipids
Muscle, Smooth, Vascular

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.