PMID: 6704051Mar 1, 1984Paper

Aortic intimal response to endothelial removal in cebus and squirrel monkeys

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
G A Hoover, K C Hayes


Whereas squirrel monkeys have an inherent susceptibility to atherosclerosis, cebus monkeys are relatively resistant. To assess whether this difference might lie in their response to endothelial injury, the acute morphologic changes in the aortic intima after endothelial removal were examined in the two species. The endothelium of the lower thoracic aorta was removed with an embolectomy catheter, and the intimal response was compared with the uninjured upper thoracic aorta in each monkey. By 21 days after aortic denudation, regrowth of the endothelium (assessed by in vivo Evans' blue dye staining) was significantly greater in squirrel monkeys (90% +/- 5% of aortic surface) than in cebus (56% +/- 11%). Squirrel monkeys had comparable sudanophilic surface in the nonballooned, control aorta (25% +/- 7%) and the ballooned, lower thoracic segment (17% +/- 6%). Cebus monkey aortas had no sudanophilia in either segment. The intima/media ratios (IMR) in all regions of the aorta were significantly greater in squirrel monkeys than in cebus, but in both species the IMR of the ventral ballooned segment was two to three times the IMR of the nonballooned control segment. In the dorsal aorta, where endothelial regrowth was more rapid, the IMR ...Continue Reading


Oct 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·R J NicolosiK C Hayes
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S H Blose
Apr 1, 1975·Experimental and Molecular Pathology·B C BullockH B Lofland
Feb 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L L Muller, T J Jacks
Oct 1, 1972·The Journal of Experimental Medicine·M B Stemerman, R R Ross
Aug 1, 1967·Canadian Journal of Psychology·H Wells, K Deffenbacher
Jul 1, 1969·Acta Oto-laryngologica·M Igarashi, T Kanda
Sep 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R Ross
May 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M A ReidyS M Schwartz
May 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G A HooverK C Hayes
Oct 1, 1964·The Journal of Cell Biology·E R WEIBEL, G E PALADE


Feb 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K C Hayes, A Pronczuk
Sep 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L M AldersonR J Nicolosi
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A K VerheyenM J Borgers

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