Aortic smooth muscle cell migration caused by platelet-derived growth factor is mediated by lipoxygenase product(s) of arachidonic acid

Biochemical and Biophysical Research Communications
J NakaoS Murota

Abstract

The relation between platelet-derived growth factor (PDGF)-induced smooth muscle cell migration, measured in Boyden chambers, and cellular arachidonic acid cascade was studied by using rat aortic smooth muscle cells. Partially purified PDGF stimulated cell migration significantly at a concentration of 1.33-133.0 micrograms/ml. Treatment of the cells with 10(-4)M of 5,8,11,14-eicosatetraynoic acid, an inhibitor of lipoxygenase and cyclooxygenase, and 10(-4)M of caffeic acid, a specific inhibitor of lipoxygenase, caused a significant suppression of PDGF-induced cell migration. Treatment with indomethacin, an inhibitor of cyclooxygenase, did not affect cell migration. These data indicate the involvement of a lipoxygenase product(s) of arachidonic acid in PDGF-associated smooth muscle cell migration.

References

Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Nov 1, 1982·Journal of Cellular Physiology·G R GrotendorstG R Martin
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W T Shier
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R GrotendorstG R Martin

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Citations

Jan 1, 1993·World Journal of Surgery·O GökçeY Güngen
Oct 23, 1985·Biochimica Et Biophysica Acta·S N MathurM L Armstrong
Mar 1, 1987·Prostaglandins, Leukotrienes, and Medicine·G H RaoJ G White
Mar 1, 1985·Molecular and Cellular Endocrinology·C H HeldinB Westermark
Oct 1, 1996·General Pharmacology·A D HughesC Demoliou-Mason
Oct 10, 1998·Kidney International·R Hakim, J Himmelfarb
Sep 1, 2005·Basic & Clinical Pharmacology & Toxicology·Yong-Ri JinYeo-Pyo Yun
Jun 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Y JeremyG D Angelini
Oct 1, 1988·The Journal of Surgical Research·M FukasawaG S diZerega
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K B Pomerantz, D P Hajjar
Oct 24, 2007·Journal of Pharmacological Sciences·Yong-Ri JinYeo-Pyo Yun
May 1, 1984·The Journal of Pharmacy and Pharmacology·E A Kitchen, W Dawson
Aug 1, 1988·The American Journal of Physiology·G E RevtyakW B Campbell
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rajiv SaranUNKNOWN Dialysis Outcomes and Practice Patterns Study
Mar 3, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T Kanayasu-ToyodaS Murota

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