PMID: 18720755Aug 30, 2008Paper

Aortic stenosis: from diagnosis to optimal treatment

Srpski arhiv za celokupno lekarstvo
Dragan Tavciovski, Zaklina Davicević

Abstract

Aortic stenosis is the most frequent valvular heart disease. Aortic sclerosis is the first characteristic lesion of the cusps, which is considered today as the process similar to atherosclerosis. Progression of the disease is an active process leading to forming of bone matrix and heavily calcified stiff cusps by inflammatory cells and osteopontin. It is a chronic, progressive disease which can remain asymptomatic for a long time even in the presence of severe aortic stenosis. Proper physical examination remains an essential diagnostic tool in aortic stenosis. Recognition of characteristic systolic murmur draws attention and guides further diagnosis in the right direction. Doppler echocardiography is an ideal tool to confirm diagnosis. It is well known that exercise tests help in stratification risk of asymptomatic aortic stenosis. Serial measurements of brain natriuretic peptide during a follow-up period may help to identify the optimal time for surgery. Heart catheterization is mostly restricted to preoperative evaluation of coronary arteries rather than to evaluation of the valve lesion itself. Currently, there is no ideal medical treatment for slowing down the disease progression. The first results about the effect of ACE i...Continue Reading

References

Apr 1, 1990·Journal of the American College of Cardiology·P A PellikkaA J Tajik
Mar 1, 1997·Journal of the American College of Cardiology·B F StewartC M Otto
Jul 25, 2000·Heart·C M Otto
Aug 31, 2000·The New England Journal of Medicine·R RosenhekH Baumgartner
Apr 18, 2003·European Heart Journal·B IungUNKNOWN Working Group on Valvular Heart Disease
Apr 30, 2003·Circulation·Nalini M RajamannanThomas Spelsberg
Sep 9, 2004·Circulation·Nalini M Rajamannan, Catherine M Otto
Sep 18, 2004·The American Journal of Cardiology·Michael WeberChristian Hamm
Nov 30, 2004·The American Journal of Cardiology·Emile R Mohler
Jun 10, 2005·The New England Journal of Medicine·S Joanna CowellUNKNOWN Scottish Aortic Stenosis and Lipid Lowering Trial, Impact on Regression (SALTIRE) Investigators
Feb 8, 2006·Circulation·John G WebbSamuel Lichtenstein

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