Aortic Stiffness and White Matter Microstructural Integrity Assessed by Diffusion Tensor Imaging: The ARIC-NCS.

Journal of the American Heart Association
Jingkai WeiGerardo Heiss

Abstract

Background Changes in white matter microstructural integrity are detectable before appearance of white matter lesions on magnetic resonance imaging as a manifestation of cerebral small-vessel disease. The information relating poor white matter microstructural integrity to aortic stiffness, a hallmark of aging, is limited. We aimed to examine the association between aortic stiffness and white matter microstructural integrity among older adults. Methods and Results We conducted a cross-sectional study to examine the association between aortic stiffness and white matter microstructural integrity among 1484 men and women (mean age, 76 years) at the 2011 to 2013 examination of the ARIC-NCS (Atherosclerosis Risk in Communities Neurocognitive Study). Aortic stiffness was measured as carotid-femoral pulse wave velocity. Cerebral white matter microstructural integrity was measured as fractional anisotropy and mean diffusivity using diffusion tensor imaging. Multivariable linear regression was used to examine the associations of carotid-femoral pulse wave velocity with fractional anisotropy and mean diffusivity of the overall cerebrum and at regions of interest. Each 1-m/s higher carotid-femoral pulse wave velocity was associated with lo...Continue Reading

References

Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M O'SullivanH S Markus
Jan 20, 2005·Reviews in the Neurosciences·Joukje M OostermanErik J A Scherder
Jun 4, 2011·Stroke; a Journal of Cerebral Circulation·Pauline MaillardCharles DeCarli
Aug 30, 2011·Biochimica Et Biophysica Acta·David J MaddenAllen W Song
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
May 2, 2014·Stroke; a Journal of Cerebral Circulation·Pauline MaillardOwen T Carmichael
May 16, 2014·European Radiology·Nathanja TjeerdemaAlbert De Roos
Jun 10, 2014·Integrated Blood Pressure Control·Salil SethiRobert Chilton
Sep 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Marius de GrootMeike W Vernooij
Dec 3, 2014·Neurobiology of Aging·Susana Muñoz ManiegaJoanna M Wardlaw
Jan 8, 2015·Stroke; a Journal of Cerebral Circulation·David S KnopmanUNKNOWN ARIC Neurocognitive Investigators
Apr 2, 2015·Neuroscience and Biobehavioral Reviews·Thomas T van SlotenCoen D A Stehouwer
Jun 6, 2015·American Journal of Hypertension·Michelle L MeyerGerardo Heiss
Sep 26, 2015·American Journal of Hypertension·Michiel SalaAlbert de Roos
Apr 23, 2016·Stroke; a Journal of Cerebral Circulation·Marco PasiLeonardo Pantoni
Nov 15, 2016·International Journal of Cardiology·Sikarin UpalaAnawin Sanguankeo
May 6, 2017·Stroke; a Journal of Cerebral Circulation·Pauline MaillardCharles DeCarli
May 25, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel BosAlbert Hofman
Sep 21, 2018·Nature Communications·Kenzo KoizumiCostantino Iadecola
Nov 22, 2018·Clinical Chemistry·Anna M Kucharska-NewtonMichelle L Meyer
Nov 23, 2018·Clinical Interventions in Aging·Lisanne TapFrancesco Us Mattace-Raso
Jan 17, 2019·Journal of the American Heart Association·Priya PaltaGerardo Heiss

❮ Previous
Next ❯

Citations

Nov 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Nick R WinderAshley E Walker

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.