Aortic stiffness is associated with cardiac function and cerebral small vessel disease in patients with type 1 diabetes mellitus: assessment by magnetic resonance imaging.

European Radiology
Saskia G C van ElderenAlbert de Roos

Abstract

To evaluate, with the use of magnetic resonance imaging (MRI), whether aortic pulse wave velocity (PWV) is associated with cardiac left ventricular (LV) function and mass as well as with cerebral small vessel disease in patients with type 1 diabetes mellitus (DM). We included 86 consecutive type 1 DM patients (49 male, mean age 46.9 +/- 11.7 years) in a prospective, cross-sectional study. Exclusion criteria included aortic/heart disease and general MRI contra-indications. MRI of the aorta, heart and brain was performed for assessment of aortic PWV, as a marker of aortic stiffness, systolic LV function and mass, as well as for the presence of cerebral white matter hyperintensities (WMHs), microbleeds and lacunar infarcts. Multivariate linear or logistic regression was performed to analyse the association between aortic PWV and outcome parameters, with covariates defined as age, gender, mean arterial pressure, heart rate, BMI, smoking, DM duration and hypertension. Mean aortic PWV was 7.1 +/- 2.5 m/s. Aortic PWV was independently associated with LV ejection fraction (ss = -0.406, P = 0.006), LV stroke volume (ss = -0.407, P = 0.001), LV cardiac output (ss = -0.458, P = 0.001), and with cerebral WMHs (P < 0.05). There were no inde...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Aug 26, 1998·Dementia and Geriatric Cognitive Disorders·F FazekasP Scheltens
Oct 20, 1999·Diabetes Care·B BrooksD K Yue
Oct 28, 1999·Cardiovascular Research·A F Leite-MoreiraT C Gillebert
Oct 21, 2000·Hypertension·M J RomanR B Devereux
Jul 31, 2001·Journal of Magnetic Resonance Imaging : JMRI·M StevanovD Grucker
Nov 5, 2003·Journal of Hypertension·Miranda T SchramUNKNOWN EURODIAB Prospective Complications Study Group
Feb 26, 2004·Lancet Neurology·Suzanne Craft, G Stennis Watson
Oct 13, 2004·Archives of Neurology·Niels D PrinsMonique M B Breteler
May 11, 2006·Cerebrovascular Diseases·Bruce Ovbiagele, Jeffrey L Saver
Jun 8, 2006·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·A M MaceiraD J Pennell
Jul 13, 2006·Clinical and Experimental Hypertension : CHE·Marcello Lastilla
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Jan 2, 2007·The American Journal of Cardiology·Andrea Di CoriAlberto Balbarini
Feb 27, 2007·Brain : a Journal of Neurology·Charlotte CordonnierJoanna Wardlaw
Jun 21, 2007·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rutger W van der MeerHildo J Lamb
Jun 22, 2007·Lancet Neurology·Sarah E VermeerPeter J Koudstaal
Dec 1, 2007·Vascular Medicine·Michael F O'Rourke
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takahiro OhmineToshiyuki Sasaguri
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Ewoud J van DijkMonique M B Breteler
Jan 24, 2009·Lancet Neurology·Steven M GreenbergUNKNOWN Microbleed Study Group
Aug 28, 2009·Journal of Magnetic Resonance Imaging : JMRI·Heynric B GrotenhuisAlbert de Roos

❮ Previous
Next ❯

Citations

Mar 12, 2011·The International Journal of Cardiovascular Imaging·A BrandtsA de Roos
Feb 24, 2011·AJR. American Journal of Roentgenology·Saskia G C van ElderenAlbert de Roos
Jun 19, 2014·Journal of Cardiothoracic Surgery·Emaddin KidherThanos Athanasiou
Oct 31, 2013·The International Journal of Cardiovascular Imaging·Eleanore S J KrönerJos J M Westenberg
Mar 29, 2011·The International Journal of Cardiovascular Imaging·E E van der WallM J Schalij
May 16, 2014·European Radiology·Nathanja TjeerdemaAlbert De Roos
Dec 3, 2014·Ultrasound in Medicine & Biology·Monika TurkMarjan Zaletel
Jan 3, 2012·Heart and Vessels·Michaela KozakovaCarlo Palombo
Feb 24, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Monika TurkJanja Pretnar Oblak
Oct 30, 2010·Journal of Magnetic Resonance Imaging : JMRI·Jos J M WestenbergJohan H C Reiber
Mar 29, 2014·Journal of Magnetic Resonance Imaging : JMRI·Eleanore S J KrönerJos J M Westenberg
Feb 17, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nathalie Thorin-TrescasesEric Thorin
Jul 4, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Kui Kai LauPeter M Rothwell
Jul 15, 2015·Hypertension·Raymond R TownsendUNKNOWN American Heart Association Council on Hypertension
Aug 11, 2012·Stroke; a Journal of Cerebral Circulation·Mariëlle M F PoelsM Arfan Ikram
Jun 1, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Mikko P TulppoHeikki V Huikuri
Dec 16, 2018·Diabetes Care·Lena M ThornUNKNOWN FinnDiane Study Group
Jun 4, 2020·Pflügers Archiv : European journal of physiology·Dorien G De MunckPaul Fransen
Sep 27, 2018·Cardiovascular Ultrasound·Jing ZhangBenyu Jiang
Apr 27, 2019·Frontiers in Cardiovascular Medicine·Hack-Lyoung Kim, Sang-Hyun Kim
Jun 13, 2020·Diabetes Care·Marika I ErikssonUNKNOWN FinnDiane Study Group
May 2, 2013·Alzheimer Disease and Associated Disorders·Wenjun ZhongCharles W Acher
Aug 26, 2021·BMJ Open Diabetes Research & Care·Marika I ErikssonUNKNOWN FinnDiane Study Group

❮ Previous
Next ❯

Software Mentioned

MASS
SPSS

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.