Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits

Atherosclerosis
Sandra L Pfister

Abstract

Hypercholesterolemia is considered a major risk factor in the development of atherosclerotic disease. The endothelium is the source of a number of vasoactive compounds which may be altered by the disease process. For example, synthesis of the arachidonic acid metabolite thromboxane A(2) (TXA(2)) increases in atherosclerosis. Non-selective blockade of vascular and platelet thromboxane (TP) receptors retards the progression of the disease in various animal models. We have previously identified a subset of NZW rabbits that lack only vascular (v) TP receptors, referred to as vTP-. These rabbits provide a unique model to elucidate the role of vascular TP receptors in hypercholesterolemia. Studies evaluated vascular responses to phenylephrine and acetylcholine in isolated aortic rings obtained from vTP- and vTP+ rabbits fed 0.5% cholesterol diet for a period of only 3 weeks. In the cholesterol-fed vTP- rabbits, contractions to phenylephrine were reduced compared to the vTP+ cholesterol-fed rabbits. Acetylcholine-induced relaxations were greater in cholesterol-fed vTP- rabbits compared to cholesterol-fed vTP+ rabbits. While the overall incidence of aortic lesions was small after only 3 weeks of cholesterol-feeding, results indicated a...Continue Reading

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Citations

Apr 28, 2010·Journal of Cardiovascular Pharmacology·Michel FélétouTony J Verbeuren
Apr 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Sandra L PfisterWilliam B Campbell
Jun 10, 2010·Physiological Genomics·Jefferson C FrisbeeAlexandre C d'Audiffret
Nov 23, 2010·Journal of Inflammation·Phoebe A StapletonJefferson C Frisbee
Sep 25, 2008·Prostaglandins & Other Lipid Mediators·Sandra L Pfister
Jul 14, 2017·Canadian Journal of Physiology and Pharmacology·É CarrierP D'Orléans-Juste

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