PMID: 9434683Jan 22, 1998Paper

Aortic valve grafts in the rat: evidence for rejection

The Journal of Thoracic and Cardiovascular Surgery
A MoustaphaT D Lee

Abstract

The histopathologic changes of fresh rat aortic valve allografts over time and the effect of cryopreservation were examined. Fifty-six syngeneic and allogeneic rat aortic valves were transplanted, either fresh or after cryopreservation, and then at different time points they were explanted and histologically examined in a blinded fashion. Histopathologic changes in the first week are similar in syngeneic and allogeneic grafts. Fresh syngeneic grafts and leaflets retained normal structure up to 56 days. Allogeneic grafts showed retrovalvular thrombus formation with leaflet ghosts and neointimal proliferation. Cryopreservation did not alter this process. Cardiac allograft valves in the rat model undergo changes that are characteristic of cell-mediated rejection and lead to valve failure.

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Citations

Sep 10, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Aya SaitoYutaka Takazawa
Nov 18, 2000·The Annals of Thoracic Surgery·J F LegareD B Ross
Feb 24, 2001·The Annals of Thoracic Surgery·R E ShaddyJ A Hawkins
Dec 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·R W GraussM C DeRuiter
Mar 27, 2001·Transplantation Proceedings·F OeiW Weimar
May 26, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S MoriyamaN Kitamura
Jun 5, 2001·The Annals of Thoracic Surgery·F B OeiA J Bogers
Oct 29, 2002·The Annals of Thoracic Surgery·Robert E Shaddy, John A Hawkins
Dec 22, 1999·The Journal of Surgical Research·F B OeiA J Bogers
May 21, 1999·The Journal of Thoracic and Cardiovascular Surgery·D B RossT D Lee
Sep 26, 2000·The Journal of Thoracic and Cardiovascular Surgery·J F LégaréD B Ross
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·J F LégaréT D Lee
Apr 5, 2005·Scandinavian Cardiovascular Journal : SCJ·Cheng-Hon Yap, Michael Yii
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Helmut GulbinsB Reichart
Nov 4, 2006·Expert Review of Cardiovascular Therapy·Cammon B Arrington, Robert E Shaddy
Aug 28, 2021·Frontiers in Immunology·Morgan Ashley HillT Konrad Rajab

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