Aortic Valve Sclerosis Adds to Prediction of Short-Term Mortality in Patients with Documented Coronary Atherosclerosis

Journal of Clinical Medicine
Paolo PoggioDamiano Baldassarre

Abstract

Aortic valve sclerosis (AVSc), a non-uniform thickening of leaflets with an unrestricted opening, is characterized by inflammation, lipoprotein deposition, and matrix degradation. In the general population, AVSc predicts long-term cardiovascular mortality (+50%) even after adjustment for vascular risk factors and clinical atherosclerosis. We have hypothesized that AVSc is a risk-multiplier able to predict even short-term mortality. To address this issue, we retrospectively analyzed 90-day mortality of all patients who underwent isolated coronary artery bypass grafting (CABG) at Centro Cardiologico Monzino over a ten-year period (2006-2016). We analyzed 2246 patients and 90-day all-cause mortality was 1.5% (31 deaths). We selected only patients deceased from cardiac causes (n = 29) and compared to alive patients (n = 2215). A cardiologist classified the aortic valve as no-AVSc (n = 1352) or AVSc (n = 892). Cox linear regression and integrated discrimination improvement (IDI) analyses were used to evaluate AVSc in predicting 90-day mortality. AVSc 90-day survival (97.6%) was lower than in no-AVSc (99.4%; p < 0.0001) with a hazard ratio (HR) of 4.0 (95%CI: 1.78, 9.05; p < 0.0001). The HR for AVSc, adjusted for propensity score, wa...Continue Reading

References

Jul 15, 1999·The New England Journal of Medicine·C M OttoD S Siscovick
Jan 23, 2004·Journal of the American College of Cardiology·Harish R ChandraWilliam W O'Neill
Jan 27, 2005·The American Journal of Cardiology·Herman A TaylorDaniel W Jones
Feb 7, 2009·International Journal of Cardiology·Anca I CorciuEugenio Picano
Nov 20, 2009·Atherosclerosis·Henry VölzkeMarcus Dörr
Apr 13, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Qiangjun CaiJamshid Shirani
Feb 8, 2011·The American Journal of Medicine·S Michael GharacholouPatricia A Pellikka
Jul 4, 2012·The American Journal of Cardiology·Tabita M ValentijnRobert J Stolker
Sep 4, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rebecca T HahnMichael H Picard
Nov 16, 2013·International Journal of Cardiology·Danitza PradelliPompilio Faggiano
Feb 21, 2014·European Heart Journal Cardiovascular Imaging·Frank A FlachskampfUNKNOWN European Association of Cardiovascular Imaging Document reviewers: Erwan Donal and Fausto Rigo
May 13, 2014·Journal of the American College of Cardiology·Sean CoffeyMichael J A Williams
Jul 1, 2014·Heart International·Muhammad Sharoz RabbaniHasanat Sharif
Jun 21, 2016·The Annals of Thoracic Surgery·Fabio BariliAlessandro Parolari
Apr 7, 2018·International Journal of Cardiology·Matteo Nicola Dario Di MinnoPaolo Poggio

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Citations

Jun 3, 2021·Journal of Clinical Medicine·José M Torres-ArellanoClaudia Lerma
Aug 14, 2021·Frontiers in Cardiovascular Medicine·Veronika A MyasoedovaPaolo Poggio

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Methods Mentioned

BETA
coronary artery bypass

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