Aortic vascular calcification is inversely associated with the trabecular bone score in patients receiving dialysis

Bone
Jasna AleksovaGrahame J Elder

Abstract

Progressive chronic kidney disease (CKD) confers a marked increase in risk for vascular calcification, cardiovascular disease, fracture and mortality, with likely contributing factors including dysregulated bone metabolism and mineral homeostasis. In general population studies, increased vascular calcification is directly related to mortality and inversely related to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). In patients with CKD, abnormalities in turnover, mineralization and bone volume reduce the ability of DXA to predict fracture. The trabecular bone score (TBS) obtained from lumbar spine DXA images, provides a surrogate measure of microarchitectural integrity not captured by BMD. This study aimed to examine the association of the TBS to prevalent abdominal aortic calcification (AAC) in patients with CKD receiving dialysis. We performed a cross-sectional study of dialysis patients awaiting transplantation. All patients underwent laboratory testing, lateral spinal radiographs including the abdominal aorta, DXA imaging and TBS assessment. AAC scores were determined using the Kauppila method. Correlations and linear regression models were used to determine predictors of AAC scores. 146 patien...Continue Reading

Citations

Sep 22, 2020·Ci Ji Yi Xue Za Zhi = Tzu-chi Medical Journal·Tzyy-Ling ChuangYuh-Feng Wang
Jan 12, 2019·Arthritis Research & Therapy·Zoltán SzekaneczWillem F Lems
Feb 19, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K KimY K Jeon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Jasna AleksovaGrahame J Elder
Clinical Journal of the American Society of Nephrology : CJASN
Nigel D ToussaintPeter G Kerr
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
S A JamalJoseph Beyene
© 2022 Meta ULC. All rights reserved