PMID: 6969109Sep 1, 1980Paper

Aortocoronary bypass procedures and sternotomy infections: a study of antistaphylococcal prophylaxis

Canadian Journal of Surgery. Journal Canadien De Chirurgie
T W AustinM M Goldbach

Abstract

In a prospective study of cephalothin prophylaxis for patients who underwent aortocoronary bypass an unacceptably high rate (44%) of Staphylococcus aureus sternotomy infections occurred in a placebo-treated group. In two other groups of patients, one group given cephalothin intraoperatively and the other given the antibiotic both intra- and postoperatively, such infections occurred with similar frequency (2.6% and 2.1% respectively). This study demonstrates the need for antistaphylococcal agents during aortocoronary bypass operation. No advantage is derived by extending this therapy beyond the operative period.

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