AP-VAS 2012 case report: a case of systemic MPO-ANCA-associated vasculitis that demonstrated brain infarction and immunohistochemically MPO-positive capillaries

CEN Case Reports
Atsushi KurataAkira Yamada

Abstract

We present a case of an aged male with myeloperoxidase anti-neutrophil cytoplasmic autoantibody (MPO-ANCA)-associated vasculitis with onset of brain infarction that demonstrated immunohistochemically MPO-positive capillaries at autopsy. The patient initially presented with gait difficulty and right-sided weakness. Since an imaging study revealed brain infarction, he was admitted to our hospital and medicated by antiplatelet agents. Continuous fever and elevated serum C-reactive protein (CRP), hematuria of glomerular origin, renal dysfunction, and high serum titer of MPO-ANCA were detected. Systemic toxicoderma appeared, and skin biopsy revealed small-vessel vasculitis; thus, he was diagnosed with MPO-ANCA-associated vasculitis. Steroid therapy (methylprednisolone 30 mg/day) was started, and general status improved. However, he died of shock 6 days after the start of the therapy. Autopsy revealed massive retroperitoneal hemorrhage with necrotizing small-vessel vasculitis in systemic organs including retroperitoneum, skin, brain, testes, and kidneys. Immunohistochemically, infiltration of MPO-positive white blood cells into the capillaries was occasionally observed, along with the features of MPO-positive capillaries. Cerebrovasc...Continue Reading

References

Nov 30, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P V DeshpandeD V Milford
Sep 29, 2005·Clinical and Experimental Nephrology·Masayuki IyodaTetsuzo Sugisaki
Nov 27, 2008·Journal of the Neurological Sciences·C W TangW T Chen
Jun 10, 2009·Clinical and Experimental Nephrology·Kimimasa NakabayashiToshihiko Nagasawa
Sep 8, 2009·Clinical Neurology and Neurosurgery·Bon D Ku, Hyun Young Shin
May 11, 2010·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Kentaro IsodaToshiaki Hanafusa
Oct 12, 2010·Journal of the Neurological Sciences·Ayca OzkulCanten Tataroglu
Jun 18, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S Ben SassiF Hentati

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