Apamin-sensitive and -insensitive components of inhibitory junction potentials in rat caecum: role of nitric oxide

Journal of Autonomic Pharmacology
R SerioF Bonvissuto

Abstract

1. The non-adrenergic non-cholinergic (NANC) inhibitory response to electrical field stimulation (EFS) in circular muscle from rat caecum was investigated using the single sucrose-gap technique. EFS with single pulses evoked hyperpolarization oral inhibitory function potential (IJP) of the membrane associated with muscular relaxation or with transient inhibition of spontaneous contractile activity. 2. The amplitude and the duration of the IJPs were enhanced by using train stimulation at increasing frequency. 3. Apamin (10(-7) M) reduced the amplitude of IJPs at all frequencies tested. 4. N omega-nitro-L-arginine methyl ester (L-NAME) (10(-4) M, 5 x 10(-4) M), but not D-NAME, caused a concentration dependent decrease in the amplitude of IJPs at all frequencies tested. L-Arginine (10(-3) M) prevented these effects. 5. L-NAME (5 x 10(-4) M) caused the disappearance of the apamin-resistant IJP-component, evoked by single pulse or by low frequency trains. 6. Sodium nitroprusside (SNP) (10(-4) M), a nitric oxide (NO) donor, induced hyperpolarization of membrane potential and muscular relaxation. SNP-induced effects were not affected by pretreatment of the muscle strips with effective concentrations of tetrodotoxin, apamin, and L-NAME...Continue Reading

References

Sep 15, 1979·European Journal of Pharmacology·A J Maas, A Den Hertog
Dec 1, 1992·Gastroenterology·M E Stark, J H Szurszewski
Apr 1, 1992·Acta Physiologica Scandinavica·L G NiklassonD S Delbro
Apr 1, 1992·Journal of Autonomic Pharmacology·F MulèA Postorino
Dec 1, 1991·The Journal of Physiology·M E StarkJ H Szurszewski
Oct 1, 1991·Canadian Journal of Physiology and Pharmacology·F ChristinckE E Daniel
Jan 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·M CostaC M Humphreys
Jul 1, 1987·The American Journal of Physiology·L R BerkowitzE P Orringer
Jan 1, 1972·The American Journal of Physiology·J D Wood
Jan 1, 1995·Canadian Journal of Physiology and Pharmacology·R SerioA Postorino
Mar 1, 1993·Gastroenterology·G E BoeckxstaensY M Van Maercke
Jan 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·R Bültmann, K Starke
Nov 1, 1993·Gastroenterology·K Schulze-Delrieu, B P Brown
Feb 1, 1993·Gastroenterology·M E StarkJ H Szurszewski

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Citations

Apr 25, 2012·Journal of Physiology and Biochemistry·Merhan Ragy, Eman Elbassuoni
Feb 1, 2003·European Journal of Pharmacology·Rosa SerioFlavia Mulè
May 25, 2002·British Journal of Pharmacology·Flavia MulèMaria Carmela Cerra
Dec 9, 2010·The Journal of Veterinary Medical Science·Hayato MatsuyamaTadashi Takewaki
Dec 1, 1998·The Journal of Physiology·T TakeuchiT Takewaki
Jan 13, 2005·Journal of Pharmacological Sciences·Kaori WasedaTadashi Takewaki
Jun 12, 2001·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·F HataA Fujita
Jan 21, 2006·Nature Reviews. Drug Discovery·Stuart A Lipton
Feb 24, 2001·Journal of Autonomic Pharmacology·C IvanchevaR Radomirov
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Van Crombruggen, R A Lefebvre

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