APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide

FEBS Letters
G del RioD E Bredesen

Abstract

We have previously described a novel cancer chemotherapeutic approach based on the induction of apoptosis in targeted cells by homing pro-apoptotic peptides. In order to improve this approach we developed a computational method (approach for detecting potential apoptotic peptides, APAP) to detect short PAPs, based on the prediction of the helical content of peptides, the hydrophobic moment, and the isoelectric point. PAPs are toxic against bacteria and mitochondria, but not against mammalian cells when applied extracellularly. Among other peptides, substance P was identified as a PAP and subsequently demonstrated to be a pro-apoptotic peptide experimentally. APAP thus provides a method to detect and ultimately improve pro-apoptotic peptides for chemotherapy.

References

Jan 1, 1988·Annual Review of Neuroscience·J E Maggio
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D EisenbergT C Terwilliger
Mar 1, 1984·Analytical Biochemistry·R W Moreadith, G Fiskum
Jan 1, 1995·Annual Review of Immunology·H G Boman
Jun 1, 1994·Nature Structural Biology·V Muñoz, L Serrano
Aug 2, 1996·Journal of Medicinal Chemistry·M M JavadpourM L McLaughlin
Jun 1, 1997·Nature Biotechnology·R PasqualiniE Ruoslahti
Dec 9, 1997·Cell·G S Salvesen, V M Dixit
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M JürgensmeierJ C Reed
Nov 10, 1998·The Journal of General Physiology·D LorenzM Bienert
Nov 25, 1998·Protein Science : a Publication of the Protein Society·D A Keire, M Kobayashi
Dec 10, 1998·Nucleic Acids Research·A Bairoch, R Apweiler
Nov 15, 1994·Physical Review. D·M Seriu, T P Singh
Sep 2, 1999·Nature Medicine·H M EllerbyR Pasqualini
Jun 20, 2001·The Journal of Biological Chemistry·H van EenennaamG J Pruijn
Nov 3, 2007·Cancer Research·Muzaffer CicekMerry Jo Oursler

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Citations

Aug 8, 2006·Oncogene·M FontenayE Solary
May 23, 2012·International Journal of Peptides·C PolancoJ A Castanon-Gonzalez
Jul 9, 2011·PloS One·Carlos Polanco GonzálezGabriel del Rio
Jul 19, 2012·PloS One·Jonathan G Rodríguez PlazaGabriel del Rio
Jul 2, 2014·Cell Biochemistry and Biophysics·Carlos PolancoMarili Leopold-Sordo
Jul 6, 2014·Cell Biochemistry and Biophysics·Carlos PolancoThomas Buhse
May 29, 2003·Leukemia & Lymphoma·Eric SolaryLaurent Corcos
Jul 2, 2016·Computational and Mathematical Methods in Medicine·Liliana I Barbosa-SantillánLuis F Barbosa-Santillán
Jul 11, 2002·Cell Death and Differentiation·S Castro-ObregónD E Bredesen
Feb 17, 2005·The Journal of Biological Chemistry·Victor V LemeshkoSergio Orduz
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rodrigo A Nava LaraGabriel Del Rio
Apr 8, 2014·The Journal of Biological Chemistry·Jonathan G Rodriguez PlazaGabriel Del Rio
Nov 18, 2003·The Journal of Pharmacology and Experimental Therapeutics·Renate BangGisa Tiegs

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