Apathy and Attentional Biases in Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Sarah A ChauKrista L Lanctôt

Abstract

Apathy, one of the most prevalent neuropsychiatric symptoms in Alzheimer's disease (AD), can be difficult to assess as cognition deteriorates. There is a need for more objective assessments that do not rely on patient insight, communicative capacities, or caregiver observation. We measured visual scanning behavior, using an eye-tracker, to explore attentional bias in the presence of competing stimuli to assess apathy in AD patients. Mild-to-moderate AD patients (Standardized Mini-Mental Status Examination, sMMSE >10) were assessed for apathy (Neuropsychiatric Inventory [NPI] apathy, Apathy Evaluation Scale [AES]). Participants were presented with 16 slides, each containing 4 images of different emotional themes (2 neutral, 1 social, 1 dysphoric). The duration of time spent, and fixation frequency on images were measured. Of the 36 AD patients (14 females, age = 78.2±7.8, sMMSE = 22.4±3.5) included, 17 had significant apathy (based on NPI apathy ≥4) and 19 did not. These groups had comparable age and sMMSE. Repeated-measures analysis of covariance models, controlling for total NPI, showed group (apathetic versus non-apathetic) by image (social versus dysphoric) interactions for duration (F(1,32) = 4.31, p = 0.046) and fixation f...Continue Reading

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Citations

Jul 1, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Krista L LanctôtEleenor H Abraham
Nov 12, 2016·Journal of Alzheimer's Disease : JAD·Sarah A ChauKrista L Lanctôt
Mar 28, 2019·Journal of Geriatric Psychiatry and Neurology·A VergalloG Tognoni
Mar 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ling TaoLi Feng
Jun 12, 2018·Computational and Mathematical Methods in Medicine·Jessica BeltránJean-François Dartigues
May 28, 2019·Journal of Alzheimer's Disease : JAD·Alexandra KönigPhilippe Robert

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