Apathy and brain alterations in Parkinson's disease: a multimodal imaging study

Annals of Clinical and Translational Neurology
O Lucas-JiménezNaroa Ibarretxe-Bilbao

Abstract

Apathy is a common nonmotor symptom in Parkinson's disease (PD) affecting 40% of patients. The aim of the study was to investigate brain changes and correlates of frontal, striatal, and limbic pathways related to subclinical symptoms of apathy in PD patients. Thirty-two PD patients divided into low-subclinical symptoms of apathy (LSA) (n = 18) and high-subclinical symptoms of apathy (HSA) (n = 14) and 25 healthy controls (HC) underwent a T1-weighted, diffusion-weighted, and resting-state functional MRI. Apathy was evaluated with the Lille Apathy Rating Scale. Voxel-based morphometry, tract-based spatial statistics, and resting-state functional connectivity (FC) analyses were performed with a region-of-interest approach. HSA-PD showed increased white matter axial and mean diffusivity compared with HC and increased white matter axial diffusivity compared with LSA-PD. HSA-PD showed decreased fronto-striatal and fronto-limbic FC compared with HC and decreased fronto-striatal FC compared with LSA-PD. LSA-PD showed decreased fronto-limbic but increased fronto-striatal FC (hyperconnectivity) compared with HC. No significant differences in grey matter were found. Fronto-striatal FC and white matter axial and mean diffusivity were assoc...Continue Reading

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Citations

Jul 17, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Stéphane PrangeStéphane Thobois
Feb 7, 2020·Journal of Neuroscience Research·Christina AndicaShigeki Aoki
Feb 27, 2021·Journal of the Neurological Sciences·Sule TinazRajita Sinha

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Methods Mentioned

BETA
SMA

Software Mentioned

CONN Functional Connectivity Toolbox
SPSS

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